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Research Article

Cell Type–Specific Transcriptome Analysis Reveals a Major Role for Zeb1 and miR-200b in Mouse Inner Ear Morphogenesis

  • Ronna Hertzano mail,

    rhertzano@smail.umaryland.edu

    Affiliation: Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America

    X
  • Ran Elkon,

    Affiliation: Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Kiyoto Kurima,

    Affiliation: Molecular Biology and Genetics Section, Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America

    X
  • Annie Morrisson,

    Affiliation: Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America

    X
  • Siaw-Lin Chan,

    Affiliation: Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America

    X
  • Michelle Sallin,

    Affiliation: Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America

    X
  • Andrew Biedlingmaier,

    Affiliation: Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America

    X
  • Douglas S. Darling,

    Affiliation: Department of Oral Health and Rehabilitation and Center for Genetics and Molecular Medicine, University of Louisville, Louisville, Kentucky, United States of America

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  • Andrew J. Griffith,

    Affiliation: Molecular Biology and Genetics Section, Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America

    X
  • David J. Eisenman,

    Affiliation: Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America

    X
  • Scott E. Strome

    Affiliation: Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America

    X
  • Published: September 29, 2011
  • DOI: 10.1371/journal.pgen.1002309

About the Authors

Ronna Hertzano, Annie Morrisson, Siaw-Lin Chan, Michelle Sallin, Andrew Biedlingmaier, David J. Eisenman, Scott E. Strome
Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America
Ran Elkon
Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Kiyoto Kurima, Andrew J. Griffith
Molecular Biology and Genetics Section, Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America
Douglas S. Darling
Department of Oral Health and Rehabilitation and Center for Genetics and Molecular Medicine, University of Louisville, Louisville, Kentucky, United States of America

Corresponding Author

Email: rhertzano@smail.umaryland.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RH RE SES. Performed the experiments: RH RE KK AM S-LC MS AB DJE. Analyzed the data: RH RE KK S-LC AJG DJE SES. Contributed reagents/materials/analysis tools: DSD AJG. Wrote the paper: RH RE AJG DJE SES.