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Research Article

Retrotransposon-Induced Heterochromatin Spreading in the Mouse Revealed by Insertional Polymorphisms

  • Rita Rebollo,

    Affiliations: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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  • Mohammad M. Karimi,

    Affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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  • Misha Bilenky,

    Affiliation: British Columbia Cancer Agency Genome Sciences Centre, Vancouver, Canada

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  • Liane Gagnier,

    Affiliations: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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  • Katharine Miceli-Royer,

    Affiliations: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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  • Ying Zhang,

    Affiliations: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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  • Preeti Goyal,

    Affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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  • Thomas M. Keane,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Steven Jones,

    Affiliations: Department of Medical Genetics, University of British Columbia, Vancouver, Canada, British Columbia Cancer Agency Genome Sciences Centre, Vancouver, Canada

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  • Martin Hirst,

    Affiliation: British Columbia Cancer Agency Genome Sciences Centre, Vancouver, Canada

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  • Matthew C. Lorincz mail,

    dmager@bccrc.ca (DLM); mlorincz@interchange.ubc.ca (MCL)

    Affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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  • Dixie L. Mager mail

    dmager@bccrc.ca (DLM); mlorincz@interchange.ubc.ca (MCL)

    Affiliations: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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  • Published: September 29, 2011
  • DOI: 10.1371/journal.pgen.1002301

About the Authors

Rita Rebollo, Liane Gagnier, Katharine Miceli-Royer, Ying Zhang, Dixie L. Mager
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada
Rita Rebollo, Mohammad M. Karimi, Liane Gagnier, Katharine Miceli-Royer, Ying Zhang, Preeti Goyal, Steven Jones, Matthew C. Lorincz, Dixie L. Mager
Department of Medical Genetics, University of British Columbia, Vancouver, Canada
Misha Bilenky, Steven Jones, Martin Hirst
British Columbia Cancer Agency Genome Sciences Centre, Vancouver, Canada
Thomas M. Keane
Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RR DLM MCL. Performed the experiments: RR MMK LG KM-R MB PG. Analyzed the data: MMK MB RR TMK. Contributed reagents/materials/analysis tools: YZ SJ MH. Wrote the paper: RR DLM MCL.