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Research Article

Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

  • Vardhman K. Rakyan equal contributor mail,

    equal contributor Contributed equally to this work with: Vardhman K. Rakyan, Huriya Beyan, Thomas A. Down

    v.rakyan@qmul.ac.uk (VKR); r.d.g.leslie@qmul.ac.uk (RDL)

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Huriya Beyan equal contributor,

    equal contributor Contributed equally to this work with: Vardhman K. Rakyan, Huriya Beyan, Thomas A. Down

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Thomas A. Down equal contributor,

    equal contributor Contributed equally to this work with: Vardhman K. Rakyan, Huriya Beyan, Thomas A. Down

    Affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    X
  • Mohammed I. Hawa,

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Siarhei Maslau,

    Affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    X
  • Deeqo Aden,

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Antoine Daunay,

    Affiliation: Laboratory for Functional Genomics, Fondation Jean-Dausset – CEPH, Paris, France

    X
  • Florence Busato,

    Affiliation: Laboratory for Epigenetics, Centre National de Génotypage, CEA – Institut de Génomique, Evry, France

    X
  • Charles A. Mein,

    Affiliation: The Genome Centre, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, The Sir John Vane Science Centre, London, United Kingdom

    X
  • Burkhard Manfras,

    Affiliation: Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Medical Center Ulm and Center of Excellence “Metabolic Disorders” Baden-Württemberg, Ulm, Germany

    X
  • Kerith-Rae M. Dias,

    Affiliation: The Genome Centre, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, The Sir John Vane Science Centre, London, United Kingdom

    X
  • Christopher G. Bell,

    Affiliation: UCL Cancer Institute, University College London, London, United Kingdom

    X
  • Jörg Tost,

    Affiliations: Laboratory for Functional Genomics, Fondation Jean-Dausset – CEPH, Paris, France, Laboratory for Epigenetics, Centre National de Génotypage, CEA – Institut de Génomique, Evry, France

    X
  • Bernhard O. Boehm,

    Affiliation: Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Medical Center Ulm and Center of Excellence “Metabolic Disorders” Baden-Württemberg, Ulm, Germany

    X
  • Stephan Beck,

    Affiliation: UCL Cancer Institute, University College London, London, United Kingdom

    X
  • R. David Leslie mail

    v.rakyan@qmul.ac.uk (VKR); r.d.g.leslie@qmul.ac.uk (RDL)

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Published: September 29, 2011
  • DOI: 10.1371/journal.pgen.1002300

About the Authors

Vardhman K. Rakyan, Huriya Beyan, Mohammed I. Hawa, Deeqo Aden, R. David Leslie
Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Thomas A. Down, Siarhei Maslau
The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Antoine Daunay, Jörg Tost
Laboratory for Functional Genomics, Fondation Jean-Dausset – CEPH, Paris, France
Florence Busato, Jörg Tost
Laboratory for Epigenetics, Centre National de Génotypage, CEA – Institut de Génomique, Evry, France
Charles A. Mein, Kerith-Rae M. Dias
The Genome Centre, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, The Sir John Vane Science Centre, London, United Kingdom
Burkhard Manfras, Bernhard O. Boehm
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Medical Center Ulm and Center of Excellence “Metabolic Disorders” Baden-Württemberg, Ulm, Germany
Christopher G. Bell, Stephan Beck
UCL Cancer Institute, University College London, London, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VKR SB RDL. Performed the experiments: VKR HB MIH DA AD FB CAM BM K-RMD JT. Analyzed the data: VKR HB TAD SM AD FB BM CGB JT SB RDL. Contributed reagents/materials/analysis tools: VKR TAD CGB JT BOB SB RDL. Wrote the paper: VKR TAD.