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Research Article

The Abnormal Phenotypes of Cartilage and Bone in Calcium-Sensing Receptor Deficient Mice Are Dependent on the Actions of Calcium, Phosphorus, and PTH

  • Jingning Liu equal contributor,

    equal contributor Contributed equally to this work with: Jingning Liu, Fangqiao Lv, Wen Sun

    Affiliation: State Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology, and Embryology, Nanjing Medical University, Nanjing, China

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  • Fangqiao Lv equal contributor,

    equal contributor Contributed equally to this work with: Jingning Liu, Fangqiao Lv, Wen Sun

    Affiliation: State Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology, and Embryology, Nanjing Medical University, Nanjing, China

    X
  • Wen Sun equal contributor,

    equal contributor Contributed equally to this work with: Jingning Liu, Fangqiao Lv, Wen Sun

    Affiliation: Institute of Dental Research, Stomatological College, Nanjing Medical University, Nanjing, China

    X
  • Chunxiang Tao,

    Affiliation: State Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology, and Embryology, Nanjing Medical University, Nanjing, China

    X
  • Guoxian Ding,

    Affiliation: Department of Gerontology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    X
  • Andrew Karaplis,

    Affiliation: Department of Medicine, McGill University, Montreal, Canada

    X
  • Edward Brown,

    Affiliation: Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • David Goltzman,

    Affiliation: Department of Medicine, McGill University, Montreal, Canada

    X
  • Dengshun Miao mail

    dsmiao@njmu.edu.cn

    Affiliations: State Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology, and Embryology, Nanjing Medical University, Nanjing, China, Department of Gerontology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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  • Published: September 22, 2011
  • DOI: 10.1371/journal.pgen.1002294

About the Authors

Jingning Liu, Fangqiao Lv, Chunxiang Tao, Dengshun Miao
State Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology, and Embryology, Nanjing Medical University, Nanjing, China
Wen Sun
Institute of Dental Research, Stomatological College, Nanjing Medical University, Nanjing, China
Guoxian Ding, Dengshun Miao
Department of Gerontology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Andrew Karaplis, David Goltzman
Department of Medicine, McGill University, Montreal, Canada
Edward Brown
Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: dsmiao@njmu.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DM. Performed the experiments: JL FL WS CT. Analyzed the data: JL WS GD. Contributed reagents/materials/analysis tools: GD AK EB DG. Wrote the paper: DM EB DG.