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Research Article

Bmp and Nodal Independently Regulate lefty1 Expression to Maintain Unilateral Nodal Activity during Left-Right Axis Specification in Zebrafish

  • Kelly A. Smith equal contributor,

    equal contributor Contributed equally to this work with: Kelly A. Smith, Emily Noël

    Affiliation: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands

    Current address: Institute for Molecular Biology, Brisbane, Australia

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  • Emily Noël equal contributor,

    equal contributor Contributed equally to this work with: Kelly A. Smith, Emily Noël

    Affiliation: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands

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  • Ingrid Thurlings,

    Affiliation: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands

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  • Holger Rehmann,

    Affiliation: University Medical Center Utrecht, Utrecht, The Netherlands

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  • Sonja Chocron,

    Affiliation: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands

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  • Jeroen Bakkers mail

    j.bakkers@hubrecht.eu

    Affiliations: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands, Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands

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  • Published: September 29, 2011
  • DOI: 10.1371/journal.pgen.1002289

About the Authors

Kelly A. Smith, Emily Noël, Ingrid Thurlings, Sonja Chocron, Jeroen Bakkers
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands
Holger Rehmann
University Medical Center Utrecht, Utrecht, The Netherlands
Jeroen Bakkers
Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands

Corresponding Author

Email: j.bakkers@hubrecht.eu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KAS EN JB. Performed the experiments: KAS EN SC IT. Analyzed the data: KAS EN JB HR. Wrote the paper: KAS EN JB.