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Research Article

Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function

  • Ching-Ti Liu equal contributor,

    equal contributor Contributed equally to this work with: Ching-Ti Liu, Maija K. Garnaas

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Maija K. Garnaas equal contributor,

    equal contributor Contributed equally to this work with: Ching-Ti Liu, Maija K. Garnaas

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America

    X
  • Adrienne Tin,

    Affiliation: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Anna Kottgen,

    Affiliations: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Renal Division, University Hospital of Freiburg, Freiburg, Germany

    X
  • Nora Franceschini,

    Affiliation: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Carmen A. Peralta,

    Affiliation: Division of Nephrology, University of California San Francisco Medical School and San Francisco VA Medical Center, San Francisco, California, United States of America

    X
  • Ian H. de Boer,

    Affiliation: Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, United States of America

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  • Xiaoning Lu,

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Elizabeth Atkinson,

    Affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Jingzhong Ding,

    Affiliation: Gerontology and Geriatric Medicine, J. Paul Sticht Center on Aging, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

    X
  • Michael Nalls,

    Affiliation: Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Daniel Shriner,

    Affiliation: Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America

    X
  • Josef Coresh,

    Affiliation: Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Abdullah Kutlar,

    Affiliation: Medical College of Georgia, Augusta, Georgia, United States of America

    X
  • Kirsten Bibbins-Domingo,

    Affiliation: University of California San Francisco, San Francisco, California, United States of America

    X
  • David Siscovick,

    Affiliation: Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Ermeg Akylbekova,

    Affiliation: Jackson State University, Jackson, Mississippi, United States of America

    X
  • Sharon Wyatt,

    Affiliation: School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

    X
  • Brad Astor,

    Affiliation: Department of Epidemiology, Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    X
  • Josef Mychaleckjy,

    Affiliation: Center for Public Health Genomics, Charlottesville, Virginia, United States of America

    X
  • Man Li,

    Affiliation: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Muredach P. Reilly,

    Affiliation: Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Raymond R. Townsend,

    Affiliation: Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Adebowale Adeyemo,

    Affiliation: Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America

    X
  • Alan B. Zonderman,

    Affiliation: Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

    X
  • Mariza de Andrade,

    Affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Stephen T. Turner,

    Affiliation: Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Thomas H. Mosley,

    Affiliation: Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

    X
  • Tamara B. Harris,

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • The CKDGen Consortium,
  • Charles N. Rotimi,

    Affiliation: Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America

    X
  • Yongmei Liu,

    Affiliation: Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, United States of America

    X
  • Sharon L. R. Kardia,

    Affiliation: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America

    X
  • Michele K. Evans,

    Affiliation: Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

    X
  • Michael G. Shlipak,

    Affiliation: General Internal Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Holly Kramer,

    Affiliation: Loyola University, Maywood, Illinois, United States of America

    X
  • Michael F. Flessner,

    Affiliation: Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Albert W. Dreisbach,

    Affiliation: University of Mississippi Division of Nephrology, University of Mississippi, Jackson, Mississippi, United States of America

    X
  • Wolfram Goessling mail,

    foxca@nhlbi.nih.gov (CSF); wkao@jhsph.edu (WLK); wgoessling@partners.org (WG)

    Affiliations: Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America, Divisions of Genetics and Gastroenterology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • L. Adrienne Cupples,

    Affiliation: Department of Biostatistics, Boston University School of Public Health and National Heart, Blood, and Lung Institute's Framingham Heart Study, Boston, Massachusetts, United States of America

    These authors were joint senior authors on this work.

    X
  • W. Linda Kao mail,

    foxca@nhlbi.nih.gov (CSF); wkao@jhsph.edu (WLK); wgoessling@partners.org (WG)

    Affiliation: Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America

    X
  • Caroline S. Fox mail

    foxca@nhlbi.nih.gov (CSF); wkao@jhsph.edu (WLK); wgoessling@partners.org (WG)

    Affiliations: National Heart, Blood, and Lung Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America, Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: September 08, 2011
  • DOI: 10.1371/journal.pgen.1002264

About the Authors

Ching-Ti Liu, Xiaoning Lu
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
Maija K. Garnaas
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Maija K. Garnaas, Wolfram Goessling, W. Linda Kao
Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America
Adrienne Tin, Anna Kottgen, Man Li
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America
Anna Kottgen
Renal Division, University Hospital of Freiburg, Freiburg, Germany
Nora Franceschini
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Carmen A. Peralta
Division of Nephrology, University of California San Francisco Medical School and San Francisco VA Medical Center, San Francisco, California, United States of America
Ian H. de Boer
Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, United States of America
Elizabeth Atkinson, Mariza de Andrade
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America
Jingzhong Ding
Gerontology and Geriatric Medicine, J. Paul Sticht Center on Aging, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America
Michael Nalls
Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, Maryland, United States of America
Daniel Shriner, Adebowale Adeyemo, Charles N. Rotimi
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America
Josef Coresh
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America
Abdullah Kutlar
Medical College of Georgia, Augusta, Georgia, United States of America
Kirsten Bibbins-Domingo
University of California San Francisco, San Francisco, California, United States of America
David Siscovick
Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, Seattle, Washington, United States of America
Ermeg Akylbekova
Jackson State University, Jackson, Mississippi, United States of America
Sharon Wyatt
School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Brad Astor
Department of Epidemiology, Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Josef Mychaleckjy
Center for Public Health Genomics, Charlottesville, Virginia, United States of America
Muredach P. Reilly
Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Raymond R. Townsend
Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Alan B. Zonderman
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Stephen T. Turner
Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America
Thomas H. Mosley
Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Tamara B. Harris
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
Yongmei Liu
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, United States of America
Sharon L. R. Kardia
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America
Michele K. Evans
Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Michael G. Shlipak
General Internal Medicine, University of California San Francisco, San Francisco, California, United States of America
Holly Kramer
Loyola University, Maywood, Illinois, United States of America
Michael F. Flessner
Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Albert W. Dreisbach
University of Mississippi Division of Nephrology, University of Mississippi, Jackson, Mississippi, United States of America
Wolfram Goessling
Divisions of Genetics and Gastroenterology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
L. Adrienne Cupples
Department of Biostatistics, Boston University School of Public Health and National Heart, Blood, and Lung Institute's Framingham Heart Study, Boston, Massachusetts, United States of America
Caroline S. Fox
National Heart, Blood, and Lung Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America
Caroline S. Fox
Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: A Adeyemo, CN Rotimi, MK Evans, AB Zonderman, Y Liu, TB Harris, J Ding, SLR Kardia, WL Kao, CS Fox. Performed the experiments: A Adeyemo, CN Rotimi, MK Evans, AB Zonderman, Y Liu, TB Harris, J Ding, SLR Kardia, ST Turner, J Coresh, D Shriner, MG Shlipak, H Kramer, AW Dreisbach, WL Kao, CS Fox. Analyzed the data: A Adeyemo, D Shriner, AB Zonderman, M Nalls, Y Liu, TB Harris, J Ding, SLR Kardia, M de Andrade, ST Turner, E Akylbekova, MF Flessner, C-T Liu, A Tin, A Kottgen, N Francheschini, CA Peralta, IH de Boer, X Lu, M Li, AW Dreisbach, LA Cupples, WL Kao, CS Fox. Wrote the paper: SLR Kardia, MF Flessner, MK Garnaas, W Goessling, C-T Liu, A Tin, A Kottgen, N Francheschini, CA Peralta, IH de Boer, LA Cupples, WL Kao, CS Fox. Subject recruitment: A Adeyemo, CN Rotimi, MK Evans, AB Zonderman, TB Harris, ST Turner, J Coresh,, D Siscovick, WL Kao, CS Fox. Critical review of manuscript: CS Fox C-T Liu, MK Garnaas, A Tin, A Kottgen, N Franceschini, CA Peralta, IH de Boer, X Lu, E Atkinson, J Ding, M Nalls, D Shriner, J Coresh, A Kutlar, K Bibbins-Domingo, D Siscovick, E Akylbekova, S Wyatt, B Astor, J Mychaleckjy, M Li, MP Reilly, RR Townsend, A Adeyemo, AB Zonderman, M de Andrade, ST Turner, TH Mosley, TB Harris, CKDGen Consortium, CN Rotimi, Y Liu, SLR Kardia, MK Evans, MG Shlipak, H Kramer, MF Flessner, AW Dreisbach, W Goessling, LA Cupples, WL Kao. Statistical methods and analysis: A Adeyemo, D Shriner, M Nalls, Y Liu, J Ding, M de Andrade, E Akylbekova, SLR Kardia, MK Garnaas, W Goessling, C-T Liu, A Tin, A Kottgen, X Lu, E Atkinson, M Li, LA Cupples WL Kao, CS Fox. Genotyping: A Adeyemo, D Shriner, M Nalls, Y Liu, M de Andrade, LA Cupples, WL Kao. Bioinformatics: M Nalls, C-T Liu. Zebrafish Work: MK Garnaas, W Goessling. Study management: D Siscovick.