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Research Article

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells

  • Ayal Hendel equal contributor,

    equal contributor Contributed equally to this work with: Ayal Hendel, Peter H. L. Krijger

    Affiliation: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

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  • Peter H. L. Krijger equal contributor,

    equal contributor Contributed equally to this work with: Ayal Hendel, Peter H. L. Krijger

    Affiliation: Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Noam Diamant,

    Affiliation: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

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  • Zohar Goren,

    Affiliation: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

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  • Petra Langerak,

    Affiliation: Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Jungmin Kim,

    Affiliation: Department of Radiation Oncology and Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Thomas Reißner,

    Affiliation: Department of Chemistry and Biochemistry, Ludwig Maximilians-University Munich, Munich, Germany

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  • Kyoo-young Lee,

    Affiliation: Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Nicholas E. Geacintov,

    Affiliation: Chemistry Department, New York University, New York, United States of America

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  • Thomas Carell,

    Affiliation: Department of Chemistry and Biochemistry, Ludwig Maximilians-University Munich, Munich, Germany

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  • Kyungjae Myung,

    Affiliation: Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Satoshi Tateishi,

    Affiliation: Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan

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  • Alan D'Andrea,

    Affiliation: Department of Radiation Oncology and Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Heinz Jacobs mail,

    zvi.livneh@weizmann.ac.il (ZL); h.jacobs@nki.nl (HJ)

    Affiliation: Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    These authors also contributed equally to this work.

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  • Zvi Livneh mail

    zvi.livneh@weizmann.ac.il (ZL); h.jacobs@nki.nl (HJ)

    Affiliation: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

    These authors also contributed equally to this work.

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  • Published: September 08, 2011
  • DOI: 10.1371/journal.pgen.1002262

About the Authors

Ayal Hendel, Noam Diamant, Zohar Goren, Zvi Livneh
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Peter H. L. Krijger, Petra Langerak, Heinz Jacobs
Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Jungmin Kim, Alan D'Andrea
Department of Radiation Oncology and Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Thomas Reißner, Thomas Carell
Department of Chemistry and Biochemistry, Ludwig Maximilians-University Munich, Munich, Germany
Kyoo-young Lee, Kyungjae Myung
Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Nicholas E. Geacintov
Chemistry Department, New York University, New York, United States of America
Satoshi Tateishi
Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AH PHLK ND ZG. Performed the experiments: AH PHLK ND ZG. Analyzed the data: AH PHLK ND ZG HJ ZL. Contributed reagents/materials/analysis tools: PL JK TR KL NEG TC KM ST AD HJ. Wrote the paper: ZL AH.