Advertisement
Research Article

Natural Polymorphism in BUL2 Links Cellular Amino Acid Availability with Chronological Aging and Telomere Maintenance in Yeast

  • Elizabeth X. Kwan,

    Affiliations: Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Molecular and Cellular Biology Program, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Eric Foss,

    Affiliation: Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Leonid Kruglyak,

    Affiliation: Lewis-Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America

    X
  • Antonio Bedalov mail

    abedalov@fhcrc.org

    Affiliations: Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Molecular and Cellular Biology Program, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Published: August 25, 2011
  • DOI: 10.1371/journal.pgen.1002250

About the Authors

Elizabeth X. Kwan, Eric Foss, Antonio Bedalov
Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Elizabeth X. Kwan, Antonio Bedalov
Molecular and Cellular Biology Program, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Leonid Kruglyak
Lewis-Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
Antonio Bedalov
Department of Medicine, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: abedalov@fhcrc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EXK AB. Performed the experiments: EXK. Analyzed the data: EXK EF AB. Contributed reagents/materials/analysis tools: EXK LK AB. Wrote the paper: EXK AB.