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Research Article

Mutations in fam20b and xylt1 Reveal That Cartilage Matrix Controls Timing of Endochondral Ossification by Inhibiting Chondrocyte Maturation

  • B. Frank Eames mail,

    bfeame@uoneuro.uoregon.edu

    Affiliation: Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America

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  • Yi-Lin Yan,

    Affiliation: Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America

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  • Mary E. Swartz,

    Affiliation: Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America

    Current address: Department of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology and Institute for Neuroscience, University of Texas, Austin, Texas, United States of America

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  • Daniel S. Levic,

    Affiliation: Department of Medicine and Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Ela W. Knapik,

    Affiliation: Department of Medicine and Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, United States of America

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  • John H. Postlethwait,

    Affiliation: Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America

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  • Charles B. Kimmel

    Affiliation: Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America

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  • Published: August 25, 2011
  • DOI: 10.1371/journal.pgen.1002246

About the Authors

B. Frank Eames, Yi-Lin Yan, Mary E. Swartz, John H. Postlethwait, Charles B. Kimmel
Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America
Daniel S. Levic, Ela W. Knapik
Department of Medicine and Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, United States of America

Corresponding Author

Email: bfeame@uoneuro.uoregon.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BFE EWK JHP CBK. Performed the experiments: BFE DSL Y-LY MES. Analyzed the data: BFE Y-LY MES DSL EWK JHP CBK. Contributed reagents/materials/analysis tools: BFE Y-LY MES EWK CBK. Wrote the paper: BFE.