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Research Article

The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO

  • Gizem Rizki,

    Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

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  • Terri Naoko Iwata,

    Affiliation: Department of Molecular Biology and Genetics, Field of Comparative Biomedical Sciences, Cornell University, Ithaca, New York, United States of America

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  • Ji Li,

    Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

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  • Christian G. Riedel,

    Affiliation: Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Simches Research Center, Boston, Massachusetts, United States of America

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  • Colette Lafontaine Picard,

    Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

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  • Max Jan,

    Affiliation: Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

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  • Coleen T. Murphy,

    Affiliation: Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

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  • Siu Sylvia Lee mail

    sylvia.lee@cornell.edu

    Affiliations: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America, Department of Molecular Biology and Genetics, Field of Comparative Biomedical Sciences, Cornell University, Ithaca, New York, United States of America

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  • Published: September 01, 2011
  • DOI: 10.1371/journal.pgen.1002235

About the Authors

Gizem Rizki, Ji Li, Colette Lafontaine Picard, Siu Sylvia Lee
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
Terri Naoko Iwata, Siu Sylvia Lee
Department of Molecular Biology and Genetics, Field of Comparative Biomedical Sciences, Cornell University, Ithaca, New York, United States of America
Christian G. Riedel
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Simches Research Center, Boston, Massachusetts, United States of America
Max Jan, Coleen T. Murphy
Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

Corresponding Author

Email: sylvia.lee@cornell.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GR TNI JL CGR CLP MJ CTM SSL. Performed the experiments: GR TNI JL CGR CLP MJ. Analyzed the data: GR TNI JL CGR CLP MJ CTM SSL. Contributed reagents/materials/analysis tools: GR TNI JL CGR CLP MJ. Wrote the paper: GR TNI CTM SSL. Performed all C. elegans experiments except CoIPs and sir-2.1O/E microarrays: GR. Performed all mammalian experiments: TNI. Performed C. elegans CoIPs of HCF-1 and SIR-2.1: JL. Performed mass spec and 14-3-3 CoIPs: CGR. Performed sir-2.1O/E microarrays: MJ CTM. Assisted with microarray analysis: CLP.