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Research Article

Temporal Dynamics of Host Molecular Responses Differentiate Symptomatic and Asymptomatic Influenza A Infection

  • Yongsheng Huang,

    Affiliations: Center for Computational Biology and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Statistics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Aimee K. Zaas,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Medicine, Duke University, Durham, North Carolina, United States of America

    X
  • Arvind Rao,

    Affiliation: Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

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  • Nicolas Dobigeon,

    Affiliation: IRIT/INP-ENSEEIHT, University of Toulouse, Toulouse, France

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  • Peter J. Woolf,

    Affiliations: Center for Computational Biology and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Timothy Veldman,

    Affiliation: Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • N. Christine Øien,

    Affiliation: Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Micah T. McClain,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Jay B. Varkey,

    Affiliation: Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, United States of America

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  • Bradley Nicholson,

    Affiliation: Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Lawrence Carin,

    Affiliation: Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, United States of America

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  • Stephen Kingsmore,

    Affiliation: Center for Pediatric Genomic Medicine, Children's Mercy Hospital, Kansas City, Missouri, United States of America

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  • Christopher W. Woods,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Geoffrey S. Ginsburg mail,

    geoffrey.ginsburg@duke.edu (GSG); hero@eecs.umich.edu (AOH)

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Alfred O. Hero III mail

    geoffrey.ginsburg@duke.edu (GSG); hero@eecs.umich.edu (AOH)

    Affiliations: Center for Computational Biology and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Statistics, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: August 25, 2011
  • DOI: 10.1371/journal.pgen.1002234

About the Authors

Yongsheng Huang, Peter J. Woolf, Alfred O. Hero III
Center for Computational Biology and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America
Yongsheng Huang, Alfred O. Hero III
Department of Statistics, University of Michigan, Ann Arbor, Michigan, United States of America
Aimee K. Zaas, Micah T. McClain, Christopher W. Woods, Geoffrey S. Ginsburg
Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
Aimee K. Zaas, Timothy Veldman, N. Christine Øien, Micah T. McClain, Bradley Nicholson, Christopher W. Woods, Geoffrey S. Ginsburg
Department of Medicine, Duke University, Durham, North Carolina, United States of America
Arvind Rao
Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
Nicolas Dobigeon
IRIT/INP-ENSEEIHT, University of Toulouse, Toulouse, France
Peter J. Woolf, Alfred O. Hero III
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America
Peter J. Woolf
Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America
Jay B. Varkey
Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, United States of America
Lawrence Carin
Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, United States of America
Stephen Kingsmore
Center for Pediatric Genomic Medicine, Children's Mercy Hospital, Kansas City, Missouri, United States of America
Alfred O. Hero III
Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AKZ TV CWW GSG BN. Performed the experiments: AKZ JBV CWW NCØ. Analyzed the data: YH MTM AOH. Contributed reagents/materials/analysis tools: AR ND PJW LC AOH. Wrote the paper: YH AKZ MTM SK CWW GSG AOH.