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Research Article

Suppression of Scant Identifies Endos as a Substrate of Greatwall Kinase and a Negative Regulator of Protein Phosphatase 2A in Mitosis

  • Hélène Rangone,

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

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  • Eva Wegel,

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

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  • Melanie K. Gatt,

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    Current address: inScience Communications, Wolters Kluwer, Auckland, New Zealand

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  • Eirene Yeung,

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    Current address: Imperial College School of Medicine, London, United Kingdom

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  • Alexander Flowers,

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    Current address: Department of Biotechnology and Chemical Sciences, Roosevelt University, Chicago, Illinois, United States of America

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  • Janusz Debski,

    Affiliation: Laboratory of Mass Spectrometry, Institute of Biochemistry and Biophysics, Warsaw, Poland

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  • Michal Dadlez,

    Affiliation: Laboratory of Mass Spectrometry, Institute of Biochemistry and Biophysics, Warsaw, Poland

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  • Veerle Janssens,

    Affiliation: Department of Molecular Cell Biology, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium

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  • Adelaide T. C. Carpenter,

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

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  • David M. Glover mail

    dmg25@cam.ac.uk

    Affiliation: Department of Genetics, University of Cambridge, Cambridge, United Kingdom

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  • Published: August 11, 2011
  • DOI: 10.1371/journal.pgen.1002225

About the Authors

Hélène Rangone, Eva Wegel, Melanie K. Gatt, Eirene Yeung, Alexander Flowers, Adelaide T. C. Carpenter, David M. Glover
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Janusz Debski, Michal Dadlez
Laboratory of Mass Spectrometry, Institute of Biochemistry and Biophysics, Warsaw, Poland
Veerle Janssens
Department of Molecular Cell Biology, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium

Corresponding Author

Email: dmg25@cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HR EW MKG VJ ATCC DMG. Performed the experiments: HR EW MKG EY AF JD VJ ATCC. Analyzed the data: HR EW MKG EY AF JD VJ ATCC DMG. Contributed reagents/materials/analysis tools: HR EW MKG JD VJ ATCC. Wrote the paper: HR EW ATCC DMG. Supervised the work: MD ATCC DMG.