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Research Article

A Negative Feedback Loop That Limits the Ectopic Activation of a Cell Type–Specific Sporulation Sigma Factor of Bacillus subtilis

  • Mónica Serrano,

    Affiliation: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

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  • Gonçalo Real equal contributor,

    equal contributor Contributed equally to this work with: Gonçalo Real, Joana Santos

    Affiliation: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

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  • Joana Santos equal contributor,

    equal contributor Contributed equally to this work with: Gonçalo Real, Joana Santos

    Affiliation: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

    Current address: Institute for the Biotechnology of Infectious Diseases, University of Technology, Sydney, Australia

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  • Jorge Carneiro,

    Affiliation: Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Charles P. Moran Jr.,

    Affiliation: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Adriano O. Henriques mail

    aoh@itqb.unl.pt

    Affiliation: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

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  • Published: September 15, 2011
  • DOI: 10.1371/journal.pgen.1002220

About the Authors

Mónica Serrano, Gonçalo Real, Joana Santos, Adriano O. Henriques
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal
Jorge Carneiro
Instituto Gulbenkian de Ciência, Oeiras, Portugal
Charles P. Moran Jr.
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America

Corresponding Author

Email: aoh@itqb.unl.pt

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MS CPM AOH. Performed the experiments: MS GR JS. Analyzed the data: MS GR JS JC CPM AOH. Wrote the paper: MS AOH.