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Research Article

Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations

  • Emiko Noguchi mail,

    enoguchi@md.tsukuba.ac.jp

    Affiliation: Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

    X
  • Hiromi Sakamoto,

    Affiliation: Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

    X
  • Tomomitsu Hirota,

    Affiliation: Laboratory of Respiratory Diseases, RIKEN Center for Genomic Medicine, Yokohama, Japan

    X
  • Kaori Ochiai,

    Affiliation: Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

    X
  • Yoshimasa Imoto,

    Affiliations: Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan, Departments of Otorhinolaryngology Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan

    X
  • Masafumi Sakashita,

    Affiliation: Departments of Otorhinolaryngology Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan

    X
  • Fumitake Kurosaka,

    Affiliation: Kurosaka Pediatrics and Allergy Clinic, Himji, Japan

    X
  • Akira Akasawa,

    Affiliation: Department of Allergy, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan

    X
  • Shigemi Yoshihara,

    Affiliation: Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan

    X
  • Noriko Kanno,

    Affiliation: Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan

    X
  • Yumi Yamada,

    Affiliation: Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan

    X
  • Naoki Shimojo,

    Affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan

    X
  • Yoichi Kohno,

    Affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan

    X
  • Yoichi Suzuki,

    Affiliation: Department of Public Health, Graduate School of Medicine, Chiba University, Chiba, Japan

    X
  • Mi-Jin Kang,

    Affiliation: Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    X
  • Ji-Won Kwon,

    Affiliation: Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    X
  • Soo-Jong Hong,

    Affiliation: Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    X
  • Ken Inoue,

    Affiliation: Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan

    X
  • Yu-ichi Goto,

    Affiliation: Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan

    X
  • Fumio Yamashita,

    Affiliations: Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan, Department of Psychiatry, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

    X
  • Takashi Asada,

    Affiliation: Department of Psychiatry, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

    X
  • Hiroshi Hirose,

    Affiliation: Health Center, Keio University, Tokyo, Japan

    X
  • Ikuo Saito,

    Affiliation: Health Center, Keio University, Tokyo, Japan

    X
  • Shigeharu Fujieda,

    Affiliation: Departments of Otorhinolaryngology Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan

    X
  • Nobuyuki Hizawa,

    Affiliation: Department of Respiratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

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  • Toru Sakamoto,

    Affiliation: Department of Respiratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

    X
  • Hironori Masuko,

    Affiliation: Department of Respiratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

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  • Yusuke Nakamura,

    Affiliation: Laboratory of Respiratory Diseases, RIKEN Center for Genomic Medicine, Yokohama, Japan

    X
  • Ichiro Nomura,

    Affiliation: Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan

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  • Mayumi Tamari,

    Affiliation: Laboratory of Respiratory Diseases, RIKEN Center for Genomic Medicine, Yokohama, Japan

    X
  • Tadao Arinami,

    Affiliation: Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

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  • Teruhiko Yoshida,

    Affiliation: Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

    X
  • Hirohisa Saito,

    Affiliation: Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan

    X
  • Kenji Matsumoto

    Affiliation: Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan

    X
  • Published: July 21, 2011
  • DOI: 10.1371/journal.pgen.1002170

About the Authors

Emiko Noguchi, Kaori Ochiai, Yoshimasa Imoto, Tadao Arinami
Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
Hiromi Sakamoto, Teruhiko Yoshida
Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan
Tomomitsu Hirota, Yusuke Nakamura, Mayumi Tamari
Laboratory of Respiratory Diseases, RIKEN Center for Genomic Medicine, Yokohama, Japan
Yoshimasa Imoto, Masafumi Sakashita, Shigeharu Fujieda
Departments of Otorhinolaryngology Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
Fumitake Kurosaka
Kurosaka Pediatrics and Allergy Clinic, Himji, Japan
Akira Akasawa
Department of Allergy, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan
Shigemi Yoshihara, Noriko Kanno, Yumi Yamada
Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan
Naoki Shimojo, Yoichi Kohno
Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
Yoichi Suzuki
Department of Public Health, Graduate School of Medicine, Chiba University, Chiba, Japan
Mi-Jin Kang, Ji-Won Kwon, Soo-Jong Hong
Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Ken Inoue, Yu-ichi Goto, Fumio Yamashita
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Fumio Yamashita, Takashi Asada
Department of Psychiatry, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
Hiroshi Hirose, Ikuo Saito
Health Center, Keio University, Tokyo, Japan
Nobuyuki Hizawa, Toru Sakamoto, Hironori Masuko
Department of Respiratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
Ichiro Nomura, Hirohisa Saito, Kenji Matsumoto
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan

Corresponding Author

Email: enoguchi@md.tsukuba.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: E Noguchi, K Matsumoto. Performed the experiments: S Yoshihara, S-J Hong, Y Goto, T Asada, S Fujieda, N Hizawa, Y Nakamura, M Tamari, T Arinami, T Yoshida, Y Suzuki, H Sakamoto. Analyzed the data: H Saito, T Hirota, K Ochiai, M Sakashita. Contributed reagents/materials/analysis tools: Y Imoto, F Kurosaka, A Akasawa, N Shimojo, Y Kohno, N Kanno, Y Yamada, M-J Kang, J-W Kwon, F Yamashita, K Inoue, H Hirose, I Saito, T Sakamoto, H Masuko, I Nomura. Wrote the paper: E Noguchi, K Matsumoto.