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Research Article

Differential Effects of MYH9 and APOL1 Risk Variants on FRMD3 Association with Diabetic ESRD in African Americans

  • Barry I. Freedman equal contributor mail,

    equal contributor Contributed equally to this work with: Barry I. Freedman, Carl D. Langefeld

    bfreedma@wakehealth.edu (BIF); clangefe@wakehealth.edu (CDL); dbowden@wakehealth.edu (DWB)

    Affiliation: Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Carl D. Langefeld equal contributor mail,

    equal contributor Contributed equally to this work with: Barry I. Freedman, Carl D. Langefeld

    bfreedma@wakehealth.edu (BIF); clangefe@wakehealth.edu (CDL); dbowden@wakehealth.edu (DWB)

    Affiliation: Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Lingyi Lu,

    Affiliation: Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Jasmin Divers,

    Affiliation: Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Mary E. Comeau,

    Affiliation: Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Jeffrey B. Kopp,

    Affiliation: Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Cheryl A. Winkler,

    Affiliation: Basic Research Laboratory, SAIC-Frederick, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America

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  • George W. Nelson,

    Affiliation: BSP CCR Genetics Core, SAIC-Frederick, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America

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  • Randall C. Johnson,

    Affiliations: BSP CCR Genetics Core, SAIC-Frederick, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America, Chaire de Bioinformatique, Conservatoire National des Arts et Metiers, Paris, France

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  • Nicholette D. Palmer,

    Affiliations: Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Pamela J. Hicks,

    Affiliations: Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Meredith A. Bostrom,

    Affiliations: Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Jessica N. Cooke,

    Affiliations: Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Program in Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Caitrin W. McDonough,

    Affiliations: Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Program in Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Donald W. Bowden mail

    bfreedma@wakehealth.edu (BIF); clangefe@wakehealth.edu (CDL); dbowden@wakehealth.edu (DWB)

    Affiliations: Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Section on Endocrinology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Published: June 16, 2011
  • DOI: 10.1371/journal.pgen.1002150

About the Authors

Barry I. Freedman
Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Carl D. Langefeld, Lingyi Lu, Jasmin Divers, Mary E. Comeau
Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Jeffrey B. Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Cheryl A. Winkler
Basic Research Laboratory, SAIC-Frederick, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America
George W. Nelson, Randall C. Johnson
BSP CCR Genetics Core, SAIC-Frederick, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America
Randall C. Johnson
Chaire de Bioinformatique, Conservatoire National des Arts et Metiers, Paris, France
Nicholette D. Palmer, Pamela J. Hicks, Meredith A. Bostrom, Donald W. Bowden
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Nicholette D. Palmer, Pamela J. Hicks, Meredith A. Bostrom, Jessica N. Cooke, Caitrin W. McDonough, Donald W. Bowden
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Nicholette D. Palmer, Pamela J. Hicks, Meredith A. Bostrom, Jessica N. Cooke, Caitrin W. McDonough, Donald W. Bowden
Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Jessica N. Cooke, Caitrin W. McDonough
Program in Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Donald W. Bowden
Section on Endocrinology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Corresponding Authors

Competing Interests

NIH has applied for a patent on the clinical use of MYH9 genetic testing for kidney disease susceptibility, with co-inventors CAW, GWN, RCJ, and JBK. No other author has a competing interest to declare.

Author Contributions

Conceived and designed the experiments: BIF CDL MAB CWM DWB. Performed the experiments: BIF CDL LL JD MEC JBK CAW GCN RCJ NDP PJH MAB JNC CWM DWB. Analyzed the data: BIF CDL LL JD MEC NDP PJH MAB JNC CWM DWB. Contributed reagents/materials/analysis tools: BIF JBK CAW GCN RCJ DWB. Wrote the paper: BIF CDL LL JD MEC JBK CAW GCN RCJ NDP PJH MAB JNC CWM DWB.