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Research Article

Extracellular Matrix Dynamics in Hepatocarcinogenesis: a Comparative Proteomics Study of PDGFC Transgenic and Pten Null Mouse Models

  • Keane K. Y. Lai equal contributor,

    equal contributor Contributed equally to this work with: Keane K. Y. Lai, Sufen Shang

    Affiliation: Molecular Diagnostics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    Current address: Southern California Research Center for ALPD and Cirrhosis, Department of Pathology, University of Southern California, Los Angeles, California, United States of America

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  • Sufen Shang equal contributor,

    equal contributor Contributed equally to this work with: Keane K. Y. Lai, Sufen Shang

    Affiliation: Molecular Diagnostics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Neha Lohia,

    Affiliation: Molecular Diagnostics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Garrett C. Booth,

    Affiliation: Molecular Diagnostics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Derek J. Masse,

    Affiliation: Molecular Diagnostics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Nelson Fausto,

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

    X
  • Jean S. Campbell,

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

    X
  • Laura Beretta mail

    lberetta@fhcrc.org

    Affiliation: Molecular Diagnostics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Published: June 23, 2011
  • DOI: 10.1371/journal.pgen.1002147

About the Authors

Keane K. Y. Lai, Sufen Shang, Neha Lohia, Garrett C. Booth, Derek J. Masse, Laura Beretta
Molecular Diagnostics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Nelson Fausto, Jean S. Campbell
Department of Pathology, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: lberetta@fhcrc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KKYL SS NF JSC LB. Performed the experiments: KKYL SS NL GCB DJM. Analyzed the data: KKYL SS NL LB. Contributed reagents/materials/analysis tools: NF JSC. Wrote the paper: KKYL NF JSC LB.