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Research Article

Genome-Wide Association Study of White Blood Cell Count in 16,388 African Americans: the Continental Origins and Genetic Epidemiology Network (COGENT)

  • Alexander P. Reiner equal contributor mail,

    equal contributor Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

    apreiner@u.washington.edu (APR); jgwilson2@umc.edu (JGW)

    Affiliations: Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Guillaume Lettre equal contributor,

    equal contributor Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

    Affiliations: Montreal Heart Institute, Montréal, Canada, Département de Médecine, Université de Montréal, Montréal, Canada

    X
  • Michael A. Nalls equal contributor,

    equal contributor Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Santhi K. Ganesh equal contributor,

    equal contributor Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

    Affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Rasika Mathias equal contributor,

    equal contributor Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

    Affiliation: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Melissa A. Austin equal contributor,

    equal contributor Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

    Affiliations: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology and Institute for Public Health Genetics, School of Public Health, University of Washington, Seattle, Washington, United States of America

    X
  • Eric Dean equal contributor,

    equal contributor Contributed equally to this work with: Alexander P. Reiner, Guillaume Lettre, Michael A. Nalls, Santhi K. Ganesh, Rasika Mathias, Melissa A. Austin, Eric Dean

    Affiliation: Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Sampath Arepalli,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Angela Britton,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Zhao Chen,

    Affiliation: Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America

    X
  • David Couper,

    Affiliation: Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina, United States of America

    X
  • J. David Curb,

    Affiliation: Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America

    X
  • Charles B. Eaton,

    Affiliation: Center for Primary Care and Prevention, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

    X
  • Myriam Fornage,

    Affiliation: Houston Institute of Molecular Medicine, University of Texas, Houston, Texas, United States of America

    X
  • Struan F. A. Grant,

    Affiliation: Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America

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  • Tamara B. Harris,

    Affiliation: Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

    X
  • Dena Hernandez,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Naoyuki Kamatini,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

    X
  • Brendan J. Keating,

    Affiliation: Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America

    X
  • Michiaki Kubo,

    Affiliation: Laboratory for Genotyping Development, CGM, RIKEN, Yokohama, Japan

    X
  • Andrea LaCroix,

    Affiliations: Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Leslie A. Lange,

    Affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Simin Liu,

    Affiliation: Departments of Epidemiology and Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Kurt Lohman,

    Affiliation: Center for Human Genomics, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Yan Meng,

    Affiliation: Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

    X
  • Emile R. Mohler III,

    Affiliation: Cardiovascular Division, Vascular Medicine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Solomon Musani,

    Affiliation: Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

    X
  • Yusuke Nakamura,

    Affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    X
  • Christopher J. O'Donnell,

    Affiliations: National Heart, Lung, and Blood Institute (NHLBI), Division of Cardiovascular Sciences, Bethesda, Maryland, United States of America, NHLBI's Framingham Heart Study, Framingham, Massachusetts, United States of America

    X
  • Yukinori Okada,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

    X
  • Cameron D. Palmer,

    Affiliation: Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

    X
  • George J. Papanicolaou,

    Affiliation: National Heart, Lung, and Blood Institute (NHLBI), Division of Cardiovascular Sciences, Bethesda, Maryland, United States of America

    X
  • Kushang V. Patel,

    Affiliation: Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Andrew B. Singleton,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Atsushi Takahashi,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

    X
  • Hua Tang,

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Herman A. Taylor Jr.,

    Affiliations: Jackson State University, Tougaloo College, Jackson, Mississippi, United States of America, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Kent Taylor,

    Affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

    X
  • Cynthia Thomson,

    Affiliation: Nutritional Sciences, Arizona Cancer Center, University of Arizona, Tucson, Arizona, United States of America

    X
  • Lisa R. Yanek,

    Affiliation: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Lingyao Yang,

    Affiliation: Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Elad Ziv,

    Affiliation: Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Alan B. Zonderman,

    Affiliation: Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Aaron R. Folsom ,

    Affiliation: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America

    These authors also contributed equally to this work.

    X
  • Michele K. Evans ,

    Affiliation: Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

    These authors also contributed equally to this work.

    X
  • Yongmei Liu ,

    Affiliation: Center for Human Genomics, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    These authors also contributed equally to this work.

    X
  • Diane M. Becker ,

    Affiliation: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    These authors also contributed equally to this work.

    X
  • Beverly M. Snively ,

    Affiliation: Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

    These authors also contributed equally to this work.

    X
  • James G. Wilson mail

    apreiner@u.washington.edu (APR); jgwilson2@umc.edu (JGW)

    Affiliation: Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

    X
  • Published: June 30, 2011
  • DOI: 10.1371/journal.pgen.1002108

About the Authors

Alexander P. Reiner, Andrea LaCroix
Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
Alexander P. Reiner, Melissa A. Austin, Andrea LaCroix
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Guillaume Lettre
Montreal Heart Institute, Montréal, Canada
Guillaume Lettre
Département de Médecine, Université de Montréal, Montréal, Canada
Michael A. Nalls, Sampath Arepalli, Angela Britton, Dena Hernandez, Andrew B. Singleton
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
Santhi K. Ganesh
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
Rasika Mathias, Lisa R. Yanek, Diane M. Becker
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Melissa A. Austin
Department of Epidemiology and Institute for Public Health Genetics, School of Public Health, University of Washington, Seattle, Washington, United States of America
Eric Dean, Elad Ziv
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Zhao Chen
Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America
David Couper
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina, United States of America
J. David Curb
Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America
Charles B. Eaton
Center for Primary Care and Prevention, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
Myriam Fornage
Houston Institute of Molecular Medicine, University of Texas, Houston, Texas, United States of America
Struan F. A. Grant, Brendan J. Keating
Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America
Tamara B. Harris, Kushang V. Patel
Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Naoyuki Kamatini, Yukinori Okada, Atsushi Takahashi
Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan
Michiaki Kubo
Laboratory for Genotyping Development, CGM, RIKEN, Yokohama, Japan
Leslie A. Lange
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America
Simin Liu
Departments of Epidemiology and Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Kurt Lohman, Yongmei Liu
Center for Human Genomics, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
Yan Meng, Cameron D. Palmer
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America
Emile R. Mohler III
Cardiovascular Division, Vascular Medicine Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Solomon Musani, Herman A. Taylor Jr.
Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Yusuke Nakamura
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Christopher J. O'Donnell, George J. Papanicolaou
National Heart, Lung, and Blood Institute (NHLBI), Division of Cardiovascular Sciences, Bethesda, Maryland, United States of America
Christopher J. O'Donnell
NHLBI's Framingham Heart Study, Framingham, Massachusetts, United States of America
Hua Tang
Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
Herman A. Taylor Jr.
Jackson State University, Tougaloo College, Jackson, Mississippi, United States of America
Kent Taylor
Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Cynthia Thomson
Nutritional Sciences, Arizona Cancer Center, University of Arizona, Tucson, Arizona, United States of America
Lingyao Yang, Beverly M. Snively
Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Alan B. Zonderman
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Aaron R. Folsom
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America
Michele K. Evans
Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
James G. Wilson
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: APR GL MAN SKG RM MAA ED SA AB ZC DC JDC CBE MF SFAG TBH DH NK BJK MK AL LAL SL KL YM ERM SM YN CJO YO CDP GP KP ABS AT HT HAT KT CT LRY LY EZ ABZ ARF MKE YL DMB BMS JGW. Performed the experiments: APR GL MAN RM SA AB NK KL YM CDP YL LRY. Analyzed the data: APR GL MAN RM YM CDP LRY LY BMS. Contributed reagents/materials/analysis tools: APR GL MAN SKG RM MAA ED SA AB ZC DC JDC CBE MF SFAG TBH DH NK BJK MK AL LAL SL KL YM ERM SM YN CJO YO CDP GP KP ABS AT HT HAT KT CT LRY LY EZ ABZ ARF MKE YL DMB BMS JGW. Wrote the paper: APR JGW.