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Research Article

Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J

  • Guy M. Lenk,

    Affiliation: Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Cole J. Ferguson,

    Affiliation: Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Clement Y. Chow equal contributor,

    equal contributor Contributed equally to this work with: Clement Y. Chow, Natsuko Jin

    Affiliation: Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

    Current address: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

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  • Natsuko Jin equal contributor,

    equal contributor Contributed equally to this work with: Clement Y. Chow, Natsuko Jin

    Affiliation: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Julie M. Jones,

    Affiliation: Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Adrienne E. Grant,

    Affiliation: Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Sergey N. Zolov,

    Affiliation: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Jesse J. Winters,

    Affiliation: Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Roman J. Giger,

    Affiliations: Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • James J. Dowling,

    Affiliation: Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Lois S. Weisman,

    Affiliations: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Miriam H. Meisler mail

    meislerm@umich.edu

    Affiliation: Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: June 02, 2011
  • DOI: 10.1371/journal.pgen.1002104

About the Authors

Guy M. Lenk, Cole J. Ferguson, Clement Y. Chow, Julie M. Jones, Adrienne E. Grant, Miriam H. Meisler
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
Natsuko Jin, Sergey N. Zolov, Lois S. Weisman
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America
Jesse J. Winters, Roman J. Giger, Lois S. Weisman
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
Roman J. Giger, James J. Dowling
Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America

Corresponding Author

Email: meislerm@umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GML CJF CYC LSW MHM. Performed the experiments: GML CJF CYC NJ JMJ AEG SNZ JJW. Analyzed the data: GML CJF CYC NJ JMJ AEG SNZ JJW RJG JJD LSW MHM. Wrote the paper: GML MHM.