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Research Article

FGF Signaling Regulates the Number of Posterior Taste Papillae by Controlling Progenitor Field Size

  • Camille I. Petersen equal contributor,

    equal contributor Contributed equally to this work with: Camille I. Petersen, Andrew H. Jheon

    Affiliation: Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California, United States of America

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  • Andrew H. Jheon equal contributor,

    equal contributor Contributed equally to this work with: Camille I. Petersen, Andrew H. Jheon

    Affiliation: Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Pasha Mostowfi,

    Affiliation: Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Cyril Charles,

    Affiliations: Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California, United States of America, Team “Evo-Devo of Vertebrate Dentition,” Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France

    X
  • Saunders Ching,

    Affiliation: Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Shoba Thirumangalathu,

    Affiliation: Department of Cell and Developmental Biology and the Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Denver, Colorado, United States of America

    X
  • Linda A. Barlow,

    Affiliation: Department of Cell and Developmental Biology and the Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Denver, Colorado, United States of America

    X
  • Ophir D. Klein mail

    ophir.klein@ucsf.edu

    Affiliations: Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California, United States of America, Department of Pediatrics and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Published: June 02, 2011
  • DOI: 10.1371/journal.pgen.1002098

About the Authors

Camille I. Petersen, Andrew H. Jheon, Pasha Mostowfi, Cyril Charles, Saunders Ching, Ophir D. Klein
Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California, United States of America
Cyril Charles
Team “Evo-Devo of Vertebrate Dentition,” Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
Shoba Thirumangalathu, Linda A. Barlow
Department of Cell and Developmental Biology and the Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Denver, Colorado, United States of America
Ophir D. Klein
Department of Pediatrics and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: ophir.klein@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CIP AHJ PM LAB ODK. Performed the experiments: CIP AHJ PM CC SC ST ODK. Analyzed the data: CIP AHJ PM CC SC ST LAB ODK. Contributed reagents/materials/analysis tools: CIP AHJ PM CC SC ST LAB ODK. Wrote the paper: CIP AHJ CC ST LAB ODK.