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Research Article

DNA Methylation Dynamics in Human Induced Pluripotent Stem Cells over Time

  • Koichiro Nishino,

    Affiliation: Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan

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  • Masashi Toyoda,

    Affiliation: Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan

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  • Mayu Yamazaki-Inoue,

    Affiliation: Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan

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  • Yoshihiro Fukawatase,

    Affiliation: Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan

    X
  • Emi Chikazawa,

    Affiliation: Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan

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  • Hironari Sakaguchi,

    Affiliation: Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan

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  • Hidenori Akutsu,

    Affiliation: Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan

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  • Akihiro Umezawa mail

    umezawa@1985.jukuin.keio.ac.jp

    Affiliation: Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan

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  • Published: May 26, 2011
  • DOI: 10.1371/journal.pgen.1002085

About the Authors

Koichiro Nishino, Masashi Toyoda, Mayu Yamazaki-Inoue, Yoshihiro Fukawatase, Emi Chikazawa, Hironari Sakaguchi, Hidenori Akutsu, Akihiro Umezawa
Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan

Corresponding Author

Email: umezawa@1985.jukuin.keio.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KN AU. Performed the experiments: KN MT MY-I. Analyzed the data: KN. Contributed reagents/materials/analysis tools: KN MT MY-I YF EC HS HA. Wrote the paper: KN AU.