Advertisement
Research Article

Exome Sequencing Identifies ZNF644 Mutations in High Myopia

  • Yi Shi equal contributor,

    equal contributor Contributed equally to this work with: Yi Shi, Yingrui Li

    Affiliations: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Yingrui Li equal contributor,

    equal contributor Contributed equally to this work with: Yi Shi, Yingrui Li

    Affiliation: Beijing Genome Institute at Shenzhen, Shenzhen, China

    X
  • Dingding Zhang,

    Affiliations: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Hao Zhang,

    Affiliation: Beijing Genome Institute at Shenzhen, Shenzhen, China

    X
  • Yuanfeng Li,

    Affiliation: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Fang Lu,

    Affiliations: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Xiaoqi Liu,

    Affiliations: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Fei He,

    Affiliations: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Bo Gong,

    Affiliations: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Li Cai,

    Affiliation: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Ruiqiang Li,

    Affiliation: Beijing Genome Institute at Shenzhen, Shenzhen, China

    X
  • Shihuang Liao,

    Affiliation: Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Shi Ma,

    Affiliations: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • He Lin,

    Affiliations: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Jing Cheng,

    Affiliations: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Hancheng Zheng,

    Affiliation: Beijing Genome Institute at Shenzhen, Shenzhen, China

    X
  • Ying Shan,

    Affiliation: Beijing Genome Institute at Shenzhen, Shenzhen, China

    X
  • Bin Chen,

    Affiliation: Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Jianbin Hu,

    Affiliation: Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Xin Jin,

    Affiliation: Innovative Program for Undergraduate Students, School of Bioscience and Biotechnology, South China University of Technology, Guangzhou, China

    X
  • Peiquan Zhao,

    Affiliation: The Department of Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, China

    X
  • Yiye Chen,

    Affiliation: The Department of Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, China

    X
  • Yong Zhang,

    Affiliation: Beijing Genome Institute at Shenzhen, Shenzhen, China

    X
  • Ying Lin,

    Affiliations: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Xi Li,

    Affiliation: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Yingchuan Fan,

    Affiliation: Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Huanming Yang,

    Affiliation: Beijing Genome Institute at Shenzhen, Shenzhen, China

    X
  • Jun Wang,

    Affiliation: Beijing Genome Institute at Shenzhen, Shenzhen, China

    X
  • Zhenglin Yang mail

    zhenglin.yang@hsc.utah.edu

    Affiliations: The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

    X
  • Published: June 09, 2011
  • DOI: 10.1371/journal.pgen.1002084

About the Authors

Yi Shi, Dingding Zhang, Yuanfeng Li, Fang Lu, Xiaoqi Liu, Fei He, Bo Gong, Li Cai, Shi Ma, He Lin, Jing Cheng, Ying Lin, Xi Li, Zhenglin Yang
The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China
Yi Shi, Dingding Zhang, Fang Lu, Xiaoqi Liu, Fei He, Bo Gong, Shi Ma, He Lin, Jing Cheng, Ying Lin, Zhenglin Yang
Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China
Yingrui Li, Hao Zhang, Ruiqiang Li, Hancheng Zheng, Ying Shan, Yong Zhang, Huanming Yang, Jun Wang
Beijing Genome Institute at Shenzhen, Shenzhen, China
Shihuang Liao, Bin Chen, Jianbin Hu, Yingchuan Fan
Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China
Xin Jin
Innovative Program for Undergraduate Students, School of Bioscience and Biotechnology, South China University of Technology, Guangzhou, China
Peiquan Zhao, Yiye Chen
The Department of Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, China

Corresponding Author

Email: zhenglin.yang@hsc.utah.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: Zhenglin Yang. Performed the experiments: Yi Shi, Dingding Zhang, Yuanfeng Li, Fang Lu, Fei Hi, Bo Gong, Li Cai, Shi Ma, He Lin, Jing Cheng, Ying Lin, Zhenglin Yang. Analyzed the data: Yingrui Li, Hao Zhang, Xiaoqi Liu, Ruiqiang Li, Hancheng Zheng, Ying Shan, Xin Jin, Yong Zhang, Xi Li, Huanming Yang, Jun Wang, Zhenglin Yang. Contributed reagents/materials/analysis tools: Shihuang Liao, Bin Chen, Yingchuan Fan, Jianbin Hu, Peiquan Zhao, Yiye Chen, Zhenglin Yang. Wrote the paper: Yi Shi, Zhenglin Yang. Obtained the funding: Yi Shi, Fang Lu, Zhenglin Yang.