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Research Article

Identification of Nine Novel Loci Associated with White Blood Cell Subtypes in a Japanese Population

  • Yukinori Okada mail,

    yokada@src.riken.jp

    Affiliations: Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan, Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

    X
  • Tomomitsu Hirota,

    Affiliation: Laboratory for Respiratory Diseases, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

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  • Yoichiro Kamatani,

    Affiliation: Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France

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  • Atsushi Takahashi,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

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  • Hiroko Ohmiya,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

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  • Natsuhiko Kumasaka,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

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  • Koichiro Higasa,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

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  • Yumi Yamaguchi-Kabata,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

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  • Naoya Hosono,

    Affiliation: Laboratory for Genotyping Development, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

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  • Michael A. Nalls,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Ming Huei Chen,

    Affiliations: National Heart, Lung, and Blood Institute's (NHLBI) Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Frank J. A. van Rooij,

    Affiliations: Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging (NGINCHA), The Netherlands Genomics Initiative, Leiden, The Netherlands

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  • Albert V. Smith,

    Affiliation: Icelandic Heart Association, Kopavogur, Iceland

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  • Toshiko Tanaka,

    Affiliation: Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • David J. Couper,

    Affiliation: Collaborative Studies Coordinating Center, Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Neil A. Zakai,

    Affiliation: Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States of America

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  • Luigi Ferrucci,

    Affiliation: Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Dan L. Longo,

    Affiliation: Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Dena G. Hernandez,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

    X
  • Jacqueline C. M. Witteman,

    Affiliations: Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging (NGINCHA), The Netherlands Genomics Initiative, Leiden, The Netherlands

    X
  • Tamara B. Harris,

    Affiliation: Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Christopher J. O'Donnell,

    Affiliations: National Heart, Lung, and Blood Institute's (NHLBI) Framingham Heart Study, Framingham, Massachusetts, United States of America, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

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  • Santhi K. Ganesh,

    Affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Koichi Matsuda,

    Affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Tatsuhiko Tsunoda,

    Affiliation: Laboratory for Medical Informatics, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

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  • Toshihiro Tanaka,

    Affiliation: Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

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  • Michiaki Kubo,

    Affiliation: Laboratory for Genotyping Development, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

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  • Yusuke Nakamura,

    Affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Mayumi Tamari,

    Affiliation: Laboratory for Respiratory Diseases, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

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  • Kazuhiko Yamamoto,

    Affiliation: Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

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  • Naoyuki Kamatani

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan

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  • Published: June 30, 2011
  • DOI: 10.1371/journal.pgen.1002067

About the Authors

Yukinori Okada, Atsushi Takahashi, Hiroko Ohmiya, Natsuhiko Kumasaka, Koichiro Higasa, Yumi Yamaguchi-Kabata, Naoyuki Kamatani
Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan
Yukinori Okada, Kazuhiko Yamamoto
Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Tomomitsu Hirota, Mayumi Tamari
Laboratory for Respiratory Diseases, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan
Yoichiro Kamatani
Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France
Naoya Hosono, Michiaki Kubo
Laboratory for Genotyping Development, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan
Michael A. Nalls, Dena G. Hernandez
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Ming Huei Chen, Christopher J. O'Donnell
National Heart, Lung, and Blood Institute's (NHLBI) Framingham Heart Study, Framingham, Massachusetts, United States of America
Ming Huei Chen
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Frank J. A. van Rooij, Jacqueline C. M. Witteman
Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
Frank J. A. van Rooij, Jacqueline C. M. Witteman
Netherlands Consortium for Healthy Aging (NGINCHA), The Netherlands Genomics Initiative, Leiden, The Netherlands
Albert V. Smith
Icelandic Heart Association, Kopavogur, Iceland
Toshiko Tanaka, Luigi Ferrucci
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
David J. Couper
Collaborative Studies Coordinating Center, Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Neil A. Zakai
Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States of America
Dan L. Longo
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Tamara B. Harris
Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Christopher J. O'Donnell
Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America
Santhi K. Ganesh
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
Koichi Matsuda, Yusuke Nakamura
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Tatsuhiko Tsunoda
Laboratory for Medical Informatics, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan
Toshihiro Tanaka
Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan

Corresponding Author

Email: yokada@src.riken.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: Yukinori Okada, Christopher J O'Donnell, Santhi K Ganesh, Koichi Matsuda, Toshihiro Tanaka, Michiaki Kubo, Yusuke Nakamura, Mayumi Tamari, Kazuhiko Yamamoto, Naoyuki Kamatani. Performed the experiments: Tomomitsu Hirota, Naoya Hosono, Christopher J O'Donnell, Santhi K Ganesh, Michiaki Kubo. Analyzed the data: Yukinori Okada, Yoichiro Kamatani, Atsushi Takahashi, Hiroko Ohmiya, Natsuhiko Kumasaka, Koichiro Higasa, Yumi Yamaguchi-Kabata, Michael A Nalls, Ming H Chen, Frank JA van Rooij, Albert V Smith, Toshiko Tanaka, David J Couper, Neil A Zakai, Luigi Ferrucci, Dan L Longo, Dena G Hernandez, Jacqueline CM Witteman, Tamara B Harris, Christopher J O'Donnell, Santhi K Ganesh, Tatsuhiko Tsunoda, Naoyuki Kamatani. Contributed reagents/materials/analysis tools: Christopher J O'Donnell, Santhi K Ganesh, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani. Wrote the manuscript: Yukinori Okada, Santhi K Ganesh.