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Research Article

Nuclear cGMP-Dependent Kinase Regulates Gene Expression via Activity-Dependent Recruitment of a Conserved Histone Deacetylase Complex

  • Yan Hao,

    Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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  • Ningyi Xu,

    Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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  • Andrew C. Box,

    Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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  • Laura Schaefer,

    Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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  • Kasthuri Kannan,

    Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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  • Ying Zhang,

    Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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  • Laurence Florens,

    Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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  • Christopher Seidel,

    Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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  • Michael P. Washburn,

    Affiliations: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Winfried Wiegraebe,

    Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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  • Ho Yi Mak mail

    hym@stowers.org

    Affiliations: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Published: May 05, 2011
  • DOI: 10.1371/journal.pgen.1002065

About the Authors

Yan Hao, Ningyi Xu, Andrew C. Box, Laura Schaefer, Kasthuri Kannan, Ying Zhang, Laurence Florens, Christopher Seidel, Michael P. Washburn, Winfried Wiegraebe, Ho Yi Mak
Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
Michael P. Washburn
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America
Ho Yi Mak
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

Corresponding Author

Email: hym@stowers.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HYM. Performed the experiments: YH NX ACB LS YZ HYM. Analyzed the data: YH YZ LF CS MPW HYM. Contributed reagents/materials/analysis tools: KK WW. Wrote the paper: HYM.