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Research Article

Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease

  • Wenjian Ma,

    Affiliation: Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Jim W. Westmoreland,

    Affiliation: Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Dmitry A. Gordenin,

    Affiliation: Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Mike A. Resnick mail

    resnick@niehs.nih.gov

    Affiliation: Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Published: April 28, 2011
  • DOI: 10.1371/journal.pgen.1002059

About the Authors

Wenjian Ma, Jim W. Westmoreland, Dmitry A. Gordenin, Mike A. Resnick
Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, North Carolina, United States of America

Corresponding Author

Email: resnick@niehs.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WM JWW DAG MAR. Performed the experiments: WM. Analyzed the data: WM JWW DAG MAR. Contributed reagents/materials/analysis tools: WM JWW. Wrote the paper: WM MAR.