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Research Article

Reciprocal Sign Epistasis between Frequently Experimentally Evolved Adaptive Mutations Causes a Rugged Fitness Landscape

  • Daniel J. Kvitek,

    Affiliation: Department of Genetics, Stanford University, Stanford, California, United States of America

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  • Gavin Sherlock mail

    sherlock@genome.stanford.edu

    Affiliation: Department of Genetics, Stanford University, Stanford, California, United States of America

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  • Published: April 28, 2011
  • DOI: 10.1371/journal.pgen.1002056

About the Authors

Daniel J. Kvitek, Gavin Sherlock
Department of Genetics, Stanford University, Stanford, California, United States of America

Corresponding Author

Email: sherlock@genome.stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJK GS. Performed the experiments: DJK. Analyzed the data: DJK. Contributed reagents/materials/analysis tools: DJK. Wrote the paper: DJK GS.