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Research Article

A Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells

  • Grace X. Y. Zheng equal contributor,

    equal contributor Contributed equally to this work with: Grace X. Y. Zheng, Arvind Ravi

    Affiliations: MIT Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts, United States of America, Computational and Systems Biology Graduate Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    Current address: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford School of Medicine, Stanford, California, United States of America

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  • Arvind Ravi equal contributor,

    equal contributor Contributed equally to this work with: Grace X. Y. Zheng, Arvind Ravi

    Affiliations: MIT Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Harvard-MIT Health Sciences and Technology Program, Cambridge, Massachusetts, United States of America

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  • J. Mauro Calabrese,

    Affiliations: MIT Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    Current address: Department of Genetics and the Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Lea A. Medeiros,

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Oktay Kirak,

    Affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Lucas M. Dennis,

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

    Current address: NanoString Technologies, Seattle, Washington, United States of America

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  • Rudolf Jaenisch,

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Christopher B. Burge,

    Affiliations: Computational and Systems Biology Graduate Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Phillip A. Sharp mail

    sharppa@mit.edu

    Affiliations: MIT Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: May 05, 2011
  • DOI: 10.1371/journal.pgen.1002054

About the Authors

Grace X. Y. Zheng, Arvind Ravi, J. Mauro Calabrese, Phillip A. Sharp
MIT Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts, United States of America
Grace X. Y. Zheng, Christopher B. Burge
Computational and Systems Biology Graduate Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Grace X. Y. Zheng, Arvind Ravi, J. Mauro Calabrese, Lea A. Medeiros, Lucas M. Dennis, Rudolf Jaenisch, Christopher B. Burge, Phillip A. Sharp
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Arvind Ravi
Harvard-MIT Health Sciences and Technology Program, Cambridge, Massachusetts, United States of America
Lea A. Medeiros, Oktay Kirak, Lucas M. Dennis, Rudolf Jaenisch
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: sharppa@mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GXYZ AR. Performed the experiments: GXYZ AR JMC. Analyzed the data: GXYZ AR. Contributed reagents/materials/analysis tools: LAM OK LMD RJ CBB. Wrote the paper: GXYZ AR PAS.