Advertisement
Research Article

Mouse Genome-Wide Association and Systems Genetics Identify Asxl2 As a Regulator of Bone Mineral Density and Osteoclastogenesis

  • Charles R. Farber mail,

    crf2s@virginia.edu

    Affiliations: Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America, Department of Medicine, Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia, United States of America, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America

    X
  • Brian J. Bennett,

    Affiliation: Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Luz Orozco,

    Affiliation: Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Wei Zou,

    Affiliation: Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America

    X
  • Ana Lira,

    Affiliation: Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

    X
  • Emrah Kostem,

    Affiliation: Department of Computer Science, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Hyun Min Kang,

    Affiliation: Department of Computer Science, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Nicholas Furlotte,

    Affiliation: Department of Computer Science, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Ani Berberyan,

    Affiliation: Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Anatole Ghazalpour,

    Affiliation: Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Jaijam Suwanwela,

    Affiliation: Department of Oral Biology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Thomas A. Drake,

    Affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Eleazar Eskin,

    Affiliation: Department of Computer Science, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Q. Tian Wang,

    Affiliation: Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America

    X
  • Steven L. Teitelbaum,

    Affiliation: Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America

    X
  • Aldons J. Lusis

    Affiliations: Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Published: April 07, 2011
  • DOI: 10.1371/journal.pgen.1002038

About the Authors

Charles R. Farber, Ana Lira
Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
Charles R. Farber
Department of Medicine, Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia, United States of America
Charles R. Farber
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America
Brian J. Bennett, Luz Orozco, Ani Berberyan, Anatole Ghazalpour, Aldons J. Lusis
Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Wei Zou, Steven L. Teitelbaum
Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America
Emrah Kostem, Hyun Min Kang, Nicholas Furlotte, Eleazar Eskin
Department of Computer Science, University of California Los Angeles, Los Angeles, California, United States of America
Jaijam Suwanwela
Department of Oral Biology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Thomas A. Drake
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Q. Tian Wang
Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America
Aldons J. Lusis
Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Aldons J. Lusis
Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America

Corresponding Author

Email: crf2s@virginia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CRF BJB LO WZ HMK AG JS TAD EE SLT AJL. Performed the experiments: CRF BJB LO WZ AL AB. Analyzed the data: CRF BJB LO WZ EK HMK NF. Contributed reagents/materials/analysis tools: QTW SLT. Wrote the paper: CRF AJL.