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Research Article

PTG Depletion Removes Lafora Bodies and Rescues the Fatal Epilepsy of Lafora Disease

  • Julie Turnbull,

    Affiliations: Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

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  • Anna A. DePaoli-Roach mail,

    berge.minassian@sickkids.ca (BAM); adepaoli@iupui.edu (AAD-R)

    Affiliation: Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis, Indiana, United States of America

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  • Xiaochu Zhao,

    Affiliation: Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada

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  • Miguel A. Cortez,

    Affiliation: Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada

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  • Nela Pencea,

    Affiliations: Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada, Department of Pathology and Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada

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  • Erica Tiberia,

    Affiliation: Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada

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  • Mark Piliguian,

    Affiliation: Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada

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  • Peter J. Roach,

    Affiliation: Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis, Indiana, United States of America

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  • Peixiang Wang,

    Affiliation: Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada

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  • Cameron A. Ackerley,

    Affiliation: Department of Pathology and Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada

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  • Berge A. Minassian mail

    berge.minassian@sickkids.ca (BAM); adepaoli@iupui.edu (AAD-R)

    Affiliations: Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada, Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada

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  • Published: April 28, 2011
  • DOI: 10.1371/journal.pgen.1002037

About the Authors

Julie Turnbull, Xiaochu Zhao, Nela Pencea, Erica Tiberia, Mark Piliguian, Peixiang Wang, Berge A. Minassian
Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
Julie Turnbull
Department of Molecular Genetics, University of Toronto, Toronto, Canada
Anna A. DePaoli-Roach, Peter J. Roach
Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis, Indiana, United States of America
Miguel A. Cortez, Berge A. Minassian
Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
Nela Pencea, Cameron A. Ackerley
Department of Pathology and Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JT AAD-R CAA BAM. Performed the experiments: JT XZ MAC NP MP ET PW CAA. Analyzed the data: JT BAM CAA. Contributed reagents/materials/analysis tools: AAD-R CAA BAM. Wrote the paper: JT BAM. Provided helpful insights: PJR.