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Research Article

Limited dCTP Availability Accounts for Mitochondrial DNA Depletion in Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE)

  • Emiliano González-Vioque,

    Affiliations: Laboratori de Patologia Mitocondrial, Institut de Recerca Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain, Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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  • Javier Torres-Torronteras,

    Affiliations: Laboratori de Patologia Mitocondrial, Institut de Recerca Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain, Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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  • Antoni L. Andreu,

    Affiliations: Laboratori de Patologia Mitocondrial, Institut de Recerca Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain, Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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  • Ramon Martí mail

    rmarti@ir.vhebron.net

    Affiliations: Laboratori de Patologia Mitocondrial, Institut de Recerca Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain, Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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  • Published: March 31, 2011
  • DOI: 10.1371/journal.pgen.1002035

About the Authors

Emiliano González-Vioque, Javier Torres-Torronteras, Antoni L. Andreu, Ramon Martí
Laboratori de Patologia Mitocondrial, Institut de Recerca Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
Emiliano González-Vioque, Javier Torres-Torronteras, Antoni L. Andreu, Ramon Martí
Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

Corresponding Author

Email: rmarti@ir.vhebron.net

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RM EG-V ALA. Performed the experiments: EG-V JT-T RM. Analyzed the data: EG-V RM. Wrote the paper: EG-V RM.