Advertisement
Research Article

Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption

  • Marilyn C. Cornelis equal contributor,

    equal contributor Contributed equally to this work with: Marilyn C. Cornelis, Keri L. Monda, Kai Yu, Nina Paynter

    Affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Keri L. Monda equal contributor,

    equal contributor Contributed equally to this work with: Marilyn C. Cornelis, Keri L. Monda, Kai Yu, Nina Paynter

    Affiliation: Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Kai Yu equal contributor,

    equal contributor Contributed equally to this work with: Marilyn C. Cornelis, Keri L. Monda, Kai Yu, Nina Paynter

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Nina Paynter equal contributor,

    equal contributor Contributed equally to this work with: Marilyn C. Cornelis, Keri L. Monda, Kai Yu, Nina Paynter

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Elizabeth M. Azzato,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Siiri N. Bennett,

    Affiliation: Collaborative Health Studies Coordinating Center, University of Washington, Seattle, Washington, United States of America

    X
  • Sonja I. Berndt,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Eric Boerwinkle,

    Affiliation: Division of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

    X
  • Stephen Chanock,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Nilanjan Chatterjee,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • David Couper,

    Affiliation: Department of Biostatistics, Collaborative Studies Coordinating Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Gary Curhan,

    Affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Gerardo Heiss,

    Affiliation: Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Frank B. Hu,

    Affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • David J. Hunter,

    Affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Kevin Jacobs,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Majken K. Jensen,

    Affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Peter Kraft,

    Affiliation: Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Maria Teresa Landi,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Jennifer A. Nettleton,

    Affiliation: Division of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

    X
  • Mark P. Purdue,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Preetha Rajaraman,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Eric B. Rimm,

    Affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Lynda M. Rose,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Nathaniel Rothman,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Debra Silverman,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Rachael Stolzenberg-Solomon,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Amy Subar,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Meredith Yeager,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Daniel I. Chasman mail,

    caporasn@mail.nih.gov (NEC); RMvD ephrmvd@nus.edu.sg (RMvD); dchasman@rics.bwh.harvard.edu (DIC)

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    These authors were joint senior authors on this work.

    X
  • Rob M. van Dam mail,

    caporasn@mail.nih.gov (NEC); RMvD ephrmvd@nus.edu.sg (RMvD); dchasman@rics.bwh.harvard.edu (DIC)

    Affiliation: Department of Epidemiology and Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    These authors were joint senior authors on this work.

    X
  • Neil E. Caporaso mail

    caporasn@mail.nih.gov (NEC); RMvD ephrmvd@nus.edu.sg (RMvD); dchasman@rics.bwh.harvard.edu (DIC)

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    These authors were joint senior authors on this work.

    X
  • Published: April 07, 2011
  • DOI: 10.1371/journal.pgen.1002033

About the Authors

Marilyn C. Cornelis, Frank B. Hu, David J. Hunter, Majken K. Jensen, Eric B. Rimm
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
Keri L. Monda, Gerardo Heiss
Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Kai Yu, Elizabeth M. Azzato, Sonja I. Berndt, Stephen Chanock, Nilanjan Chatterjee, Kevin Jacobs, Maria Teresa Landi, Mark P. Purdue, Preetha Rajaraman, Nathaniel Rothman, Debra Silverman, Rachael Stolzenberg-Solomon, Amy Subar, Meredith Yeager, Neil E. Caporaso
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Nina Paynter, Lynda M. Rose, Daniel I. Chasman
Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Siiri N. Bennett
Collaborative Health Studies Coordinating Center, University of Washington, Seattle, Washington, United States of America
Eric Boerwinkle, Jennifer A. Nettleton
Division of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
David Couper
Department of Biostatistics, Collaborative Studies Coordinating Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Gary Curhan
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Peter Kraft
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Rob M. van Dam
Department of Epidemiology and Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NEC RMvD MCC. Analyzed the data: MCC KLM KY NP DIC. Wrote the paper: MCC KLM KY NP DIC RMvD NEC. Genetic data provider: EBR GC FBH PK DJH DIC NEC. Study management: NEC RMvD MCC. Critical review of manuscript: MCC KLM KY NP EMA SNB SIB EB SC NC DC GC GH FBH DJH KJ MKJ PK MTL JAN MPP PR EBR LMR NR DS RS-S AS MY DIC RMvD NEC.