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Research Article

FUS Transgenic Rats Develop the Phenotypes of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration

  • Cao Huang equal contributor,

    equal contributor Contributed equally to this work with: Cao Huang, Hongxia Zhou

    Affiliation: Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Hongxia Zhou equal contributor mail,

    equal contributor Contributed equally to this work with: Cao Huang, Hongxia Zhou

    Hongxia.zhou@jefferson.edu (HZ); xugang.xia@jefferson.edu (X-GX)

    Affiliation: Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Jianbin Tong,

    Affiliation: Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Han Chen,

    Affiliation: Center for Biotechnology, University of Nebraska–Lincoln, Lincoln, Nebraska, United States of America

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  • Yong-Jian Liu,

    Affiliation: Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Dian Wang,

    Affiliation: Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Xiaotao Wei,

    Affiliation: Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Xu-Gang Xia mail

    Hongxia.zhou@jefferson.edu (HZ); xugang.xia@jefferson.edu (X-GX)

    Affiliation: Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Published: March 03, 2011
  • DOI: 10.1371/journal.pgen.1002011

About the Authors

Cao Huang, Hongxia Zhou, Jianbin Tong, Dian Wang, Xiaotao Wei, Xu-Gang Xia
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Han Chen
Center for Biotechnology, University of Nebraska–Lincoln, Lincoln, Nebraska, United States of America
Yong-Jian Liu
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors declare no conflict of interest.

Author Contributions

Conceived and designed the experiments: CH HZ XGX. Performed the experiments: CH HZ JT HC YJL DW XW XGX. Analyzed the data: CH HZ XGX. Wrote the paper: CH HZ XGX.