Advertisement
Research Article

Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

  • Alexandra Zhernakova,

    Affiliations: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Complex Genetics Section, Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Eli A. Stahl,

    Affiliations: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

    X
  • Gosia Trynka,

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

    X
  • Soumya Raychaudhuri,

    Affiliations: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Eleanora A. Festen,

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

    X
  • Lude Franke,

    Affiliations: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Harm-Jan Westra,

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

    X
  • Rudolf S. N. Fehrmann,

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

    X
  • Fina A. S. Kurreeman,

    Affiliations: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

    X
  • Brian Thomson,

    Affiliation: Broad Institute, Cambridge, Massachusetts, United States of America

    X
  • Namrata Gupta,

    Affiliation: Broad Institute, Cambridge, Massachusetts, United States of America

    X
  • Jihane Romanos,

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

    X
  • Ross McManus,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College, St James's Hospital, Dublin, Ireland

    X
  • Anthony W. Ryan,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College, St James's Hospital, Dublin, Ireland

    X
  • Graham Turner,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College, St James's Hospital, Dublin, Ireland

    X
  • Elisabeth Brouwer,

    Affiliation: Department of Rheumatology and Clinical Immunology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

    X
  • Marcel D. Posthumus,

    Affiliation: Department of Rheumatology and Clinical Immunology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

    X
  • Elaine F. Remmers,

    Affiliation: Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Francesca Tucci,

    Affiliation: European Laboratory for Food Induced Disease, University of Naples Federico II, Naples, Italy

    X
  • Rene Toes,

    Affiliation: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands

    X
  • Elvira Grandone,

    Affiliation: Unita' di Aterosclerosi e Trombosi, I.R.C.C.S Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Foggia, Italy

    X
  • Maria Cristina Mazzilli,

    Affiliation: Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

    X
  • Anna Rybak,

    Affiliation: Department of Gastroenterology, Hepatology, and Immunology, Children's Memorial Health Institute, Warsaw, Poland

    X
  • Bozena Cukrowska,

    Affiliation: Department of Pathology, Children's Memorial Health Institute, Warsaw, Poland

    X
  • Marieke J. H. Coenen,

    Affiliation: Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    X
  • Timothy R. D. J. Radstake,

    Affiliation: Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    X
  • Piet L. C. M. van Riel,

    Affiliation: Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    X
  • Yonghong Li,

    Affiliation: Celera, Alameda, California, United States of America

    X
  • Paul I. W. de Bakker,

    Affiliations: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands

    X
  • Peter K. Gregersen,

    Affiliation: The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America

    X
  • Jane Worthington,

    Affiliation: Arthritis Research Campaign–Epidemiology Unit, The University of Manchester, Manchester, United Kingdom

    X
  • Katherine A. Siminovitch,

    Affiliation: Department of Medicine, University of Toronto, Mount Sinai Hospital and University Health Network, Toronto, Canada

    X
  • Lars Klareskog,

    Affiliation: Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden

    X
  • Tom W. J. Huizinga,

    Affiliation: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands

    X
  • Cisca Wijmenga equal contributor,

    equal contributor Contributed equally to this work with: Cisca Wijmenga, Robert M. Plenge

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

    X
  • Robert M. Plenge equal contributor mail

    equal contributor Contributed equally to this work with: Cisca Wijmenga, Robert M. Plenge

    rplenge@partners.org

    Affiliations: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Published: February 24, 2011
  • DOI: 10.1371/journal.pgen.1002004

About the Authors

Alexandra Zhernakova, Fina A. S. Kurreeman, Rene Toes, Tom W. J. Huizinga
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Alexandra Zhernakova
Complex Genetics Section, Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands
Alexandra Zhernakova, Eli A. Stahl, Soumya Raychaudhuri, Fina A. S. Kurreeman, Paul I. W. de Bakker, Robert M. Plenge
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Eli A. Stahl, Soumya Raychaudhuri, Fina A. S. Kurreeman, Brian Thomson, Namrata Gupta, Paul I. W. de Bakker, Robert M. Plenge
Broad Institute, Cambridge, Massachusetts, United States of America
Gosia Trynka, Eleanora A. Festen, Lude Franke, Harm-Jan Westra, Rudolf S. N. Fehrmann, Jihane Romanos, Cisca Wijmenga
Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
Soumya Raychaudhuri
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Soumya Raychaudhuri, Robert M. Plenge
Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Lude Franke
Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Ross McManus, Anthony W. Ryan, Graham Turner
Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College, St James's Hospital, Dublin, Ireland
Elisabeth Brouwer, Marcel D. Posthumus
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
Elaine F. Remmers
Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Francesca Tucci
European Laboratory for Food Induced Disease, University of Naples Federico II, Naples, Italy
Elvira Grandone
Unita' di Aterosclerosi e Trombosi, I.R.C.C.S Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Foggia, Italy
Maria Cristina Mazzilli
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
Anna Rybak
Department of Gastroenterology, Hepatology, and Immunology, Children's Memorial Health Institute, Warsaw, Poland
Bozena Cukrowska
Department of Pathology, Children's Memorial Health Institute, Warsaw, Poland
Marieke J. H. Coenen
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Timothy R. D. J. Radstake, Piet L. C. M. van Riel
Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Yonghong Li
Celera, Alameda, California, United States of America
Paul I. W. de Bakker
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Paul I. W. de Bakker
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
Peter K. Gregersen
The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America
Jane Worthington
Arthritis Research Campaign–Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
Katherine A. Siminovitch
Department of Medicine, University of Toronto, Mount Sinai Hospital and University Health Network, Toronto, Canada
Lars Klareskog
Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden

Corresponding Author

Email: rplenge@partners.org

Competing Interests

YL has employment and stock interest in Celera.

Author Contributions

Conceived and designed the experiments: RM Plenge, C Wijmenga, A Zhernakova, EA Stahl, S Raychaudhuri. Performed the experiments: A Zhernakova, G Trynka, FAS Kurreeman, B Thomson, N Gupta, J Romanos, EF Remmers, Y Li. Analyzed the data: A Zhernakova, EA Stahl, RM Plenge, S Raychaudhuri, L Franke, RSN Fehrmann, EA Festen, FAS Kurreeman, PIW de Bakker, HJ Westra. Contributed reagents/materials/analysis tools: RM Plenge, C Wijmenga, A Zhernakova, R McManus, AW Ryan, G Turner, PK Gregersen, J Worthington, KA Siminovitch, L Klareskog, TWJ Huizinga, EF Remmers, F Tucci, R Toes, E Grandone, MC Mazzilli, A Rybak, B Cukrowska, E Brouwer, MD Posthumus, MJH Coenen, TRDJ Radstake, PLCM van Riel. Wrote the paper: RM Plenge, C Wijmenga, A Zhernakova, EA Stahl, S Raychaudhuri, FAS Kurreeman, G Trynka, R Toes, Y Li, TWJ Huizinga.