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Research Article

Characterizing Genetic Risk at Known Prostate Cancer Susceptibility Loci in African Americans

  • Christopher A. Haiman mail,

    haiman@usc.edu

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

    X
  • Gary K. Chen,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

    X
  • William J. Blot,

    Affiliations: International Epidemiology Institute, Rockville, Maryland, United States of America, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, United States of America, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States of America

    X
  • Sara S. Strom,

    Affiliation: Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Sonja I. Berndt,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Rick A. Kittles,

    Affiliation: Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

    X
  • Benjamin A. Rybicki,

    Affiliation: Department of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, Michigan, United States of America

    X
  • William B. Isaacs,

    Affiliation: James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institutions, Baltimore, Maryland, United States of America

    X
  • Sue A. Ingles,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

    X
  • Janet L. Stanford,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • W. Ryan Diver,

    Affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America

    X
  • John S. Witte,

    Affiliation: Institute for Human Genetics, Departments of Epidemiology and Biostatistics and Urology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Stephen J. Chanock,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Suzanne Kolb,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Lisa B. Signorello,

    Affiliations: International Epidemiology Institute, Rockville, Maryland, United States of America, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, United States of America, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States of America

    X
  • Yuko Yamamura,

    Affiliation: Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Christine Neslund-Dudas,

    Affiliation: Department of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, Michigan, United States of America

    X
  • Michael J. Thun,

    Affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America

    X
  • Adam Murphy,

    Affiliation: Department of Urology, Northwestern University, Chicago, Illinois, United States of America

    X
  • Graham Casey,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

    X
  • Xin Sheng,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

    X
  • Peggy Wan,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

    X
  • Loreall C. Pooler,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

    X
  • Kristine R. Monroe,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

    X
  • Kevin M. Waters,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

    X
  • Loic Le Marchand,

    Affiliation: Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America

    X
  • Laurence N. Kolonel,

    Affiliation: Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America

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  • Daniel O. Stram,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

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  • Brian E. Henderson

    Affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

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  • Published: May 26, 2011
  • DOI: 10.1371/journal.pgen.1001387

About the Authors

Christopher A. Haiman, Gary K. Chen, Sue A. Ingles, Graham Casey, Xin Sheng, Peggy Wan, Loreall C. Pooler, Kristine R. Monroe, Kevin M. Waters, Daniel O. Stram, Brian E. Henderson
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America
William J. Blot, Lisa B. Signorello
International Epidemiology Institute, Rockville, Maryland, United States of America
William J. Blot, Lisa B. Signorello
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, United States of America
William J. Blot, Lisa B. Signorello
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States of America
Sara S. Strom, Yuko Yamamura
Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
Sonja I. Berndt, Stephen J. Chanock
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Rick A. Kittles
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
Benjamin A. Rybicki, Christine Neslund-Dudas
Department of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, Michigan, United States of America
William B. Isaacs
James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institutions, Baltimore, Maryland, United States of America
Janet L. Stanford, Suzanne Kolb
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
W. Ryan Diver, Michael J. Thun
Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America
John S. Witte
Institute for Human Genetics, Departments of Epidemiology and Biostatistics and Urology, University of California San Francisco, San Francisco, California, United States of America
Adam Murphy
Department of Urology, Northwestern University, Chicago, Illinois, United States of America
Loic Le Marchand, Laurence N. Kolonel
Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America

Corresponding Author

Email: haiman@usc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CAH. Performed the experiments: SJC LP. Analyzed the data: CAH GKC XS PW DOS. Contributed reagents/materials/analysis tools: WJB SSS SIB RK BR WBI SAI JS WRD JSW SJC SK LBS YY CND MJT AM GC KRM KMW LLM LNK BEH. Wrote the paper: CAH.