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Research Article

Genomic Instability, Defective Spermatogenesis, Immunodeficiency, and Cancer in a Mouse Model of the RIDDLE Syndrome

  • Toshiyuki Bohgaki equal contributor,

    equal contributor Contributed equally to this work with: Toshiyuki Bohgaki, Miyuki Bohgaki

    Affiliation: Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Canada

    X
  • Miyuki Bohgaki equal contributor,

    equal contributor Contributed equally to this work with: Toshiyuki Bohgaki, Miyuki Bohgaki

    Affiliation: Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Canada

    X
  • Renato Cardoso,

    Affiliation: Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Canada

    X
  • Stephanie Panier,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

    X
  • Dimphy Zeegers,

    Affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    X
  • Li Li,

    Affiliation: Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Canada

    X
  • Grant S. Stewart,

    Affiliation: Cancer Research UK, Institute for Cancer Studies, Birmingham University, Birmingham, United Kingdom

    X
  • Otto Sanchez,

    Affiliation: University of Ontario Institute of Technology, Oshawa, Canada

    X
  • M. Prakash Hande,

    Affiliation: Cancer Research UK, Institute for Cancer Studies, Birmingham University, Birmingham, United Kingdom

    X
  • Daniel Durocher,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

    X
  • Anne Hakem mail,

    ahakem@uhnres.utoronto.ca (AH); rhakem@uhnres.utoronto.ca (RH)

    Affiliation: Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Canada

    X
  • Razqallah Hakem mail

    ahakem@uhnres.utoronto.ca (AH); rhakem@uhnres.utoronto.ca (RH)

    Affiliation: Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Canada

    X
  • Published: April 28, 2011
  • DOI: 10.1371/journal.pgen.1001381

About the Authors

Toshiyuki Bohgaki, Miyuki Bohgaki, Renato Cardoso, Li Li, Anne Hakem, Razqallah Hakem
Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Canada
Stephanie Panier, Daniel Durocher
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Dimphy Zeegers
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Grant S. Stewart, M. Prakash Hande
Cancer Research UK, Institute for Cancer Studies, Birmingham University, Birmingham, United Kingdom
Otto Sanchez
University of Ontario Institute of Technology, Oshawa, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TB MB AH RH. Performed the experiments: TB MB RC DZ MPH AH. Analyzed the data: TB MB OS MPH AH RH. Contributed reagents/materials/analysis tools: SP LL GSS DD. Wrote the paper: TB MB AH RH.