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Research Article

Genome-Wide Association Analysis of Soluble ICAM-1 Concentration Reveals Novel Associations at the NFKBIK, PNPLA3, RELA, and SH2B3 Loci

  • Guillaume Paré mail,

    pareg@McMaster.ca

    Affiliations: Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, McMaster University, Hamilton, Canada

    X
  • Paul M. Ridker,

    Affiliations: Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Lynda Rose,

    Affiliations: Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Maja Barbalic,

    Affiliation: Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

    X
  • Josée Dupuis,

    Affiliations: National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Abbas Dehghan,

    Affiliations: Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, The Netherlands Consortium on Healthy Aging (NCHA), Leiden, The Netherlands

    X
  • Joshua C. Bis,

    Affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Emelia J. Benjamin,

    Affiliations: National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, United States of America, Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Dov Shiffman,

    Affiliation: Celera, Alameda, California, United States of America

    X
  • Alexander N. Parker,

    Affiliation: Amgen, Cambridge, Massachusetts, United States of America

    X
  • Daniel I. Chasman

    Affiliations: Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: April 21, 2011
  • DOI: 10.1371/journal.pgen.1001374

About the Authors

Guillaume Paré, Paul M. Ridker, Lynda Rose, Daniel I. Chasman
Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Guillaume Paré, Paul M. Ridker, Lynda Rose, Daniel I. Chasman
Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Guillaume Paré
McMaster University, Hamilton, Canada
Maja Barbalic
Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
Josée Dupuis, Emelia J. Benjamin
National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, United States of America
Josée Dupuis
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
Abbas Dehghan
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Abbas Dehghan
The Netherlands Consortium on Healthy Aging (NCHA), Leiden, The Netherlands
Joshua C. Bis
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America
Emelia J. Benjamin
Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
Emelia J. Benjamin
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America
Dov Shiffman
Celera, Alameda, California, United States of America
Alexander N. Parker
Amgen, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: pareg@McMaster.ca

Competing Interests

DS is an employee of Celera.

Author Contributions

Conceived and designed the experiments: GP PMR ANP DIC. Performed the experiments: GP ANP DIC. Analyzed the data: GP LR MB. Contributed reagents/materials/analysis tools: GP PMR MB JD AD JCB EJB DS ANP DIC. Wrote the paper: GP.