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Research Article

Genome Analysis Reveals Interplay between 5′UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes

  • Can Cenik,

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Hon Nian Chua,

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Hui Zhang,

    Affiliation: Department of Biochemistry, University of Toronto, Toronto, Canada

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  • Stefan P. Tarnawsky,

    Affiliation: Department of Biochemistry, University of Toronto, Toronto, Canada

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  • Abdalla Akef,

    Affiliation: Department of Biochemistry, University of Toronto, Toronto, Canada

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  • Adnan Derti,

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Murat Tasan,

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Melissa J. Moore,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Alexander F. Palazzo mail,

    alex.palazzo@utoronto.ca (AFP); fritz_roth@hms.harvard.edu (FPR)

    Affiliation: Department of Biochemistry, University of Toronto, Toronto, Canada

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  • Frederick P. Roth mail

    alex.palazzo@utoronto.ca (AFP); fritz_roth@hms.harvard.edu (FPR)

    Affiliations: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Canada

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  • Published: April 14, 2011
  • DOI: 10.1371/journal.pgen.1001366

About the Authors

Can Cenik, Hon Nian Chua, Adnan Derti, Murat Tasan, Frederick P. Roth
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
Hui Zhang, Stefan P. Tarnawsky, Abdalla Akef, Alexander F. Palazzo
Department of Biochemistry, University of Toronto, Toronto, Canada
Melissa J. Moore
Department of Biochemistry and Molecular Pharmacology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Frederick P. Roth
Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Frederick P. Roth
Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada
Frederick P. Roth
Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CC MJM AFP FPR. Performed the experiments: CC HNC HZ SPT AA AD MT AFP. Analyzed the data: CC HNC AFP. Wrote the paper: CC AFP FPR.