Advertisement
Research Article

Quantitative Fitness Analysis Shows That NMD Proteins and Many Other Protein Complexes Suppress or Enhance Distinct Telomere Cap Defects

  • Stephen Gregory Addinall equal contributor,

    equal contributor Contributed equally to this work with: Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Eva-Maria Holstein equal contributor,

    equal contributor Contributed equally to this work with: Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Conor Lawless equal contributor,

    equal contributor Contributed equally to this work with: Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless

    Affiliation: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Min Yu,

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Kaye Chapman,

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    Current address: Health Protection Agency North East, Citygate, Newcastle upon Tyne, United Kingdom

    X
  • A. Peter Banks,

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Hien-Ping Ngo,

    Affiliation: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom

    X
  • Laura Maringele,

    Affiliation: Crucible Laboratory, Institute for Ageing and Health, Newcastle University Centre for Life, Newcastle upon Tyne, United Kingdom

    X
  • Morgan Taschuk,

    Affiliations: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom

    X
  • Alexander Young,

    Affiliations: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Mathematics and Statistics, Newcastle University, Newcastle upon Tyne, United Kingdom

    X
  • Adam Ciesiolka,

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Allyson Lurena Lister,

    Affiliations: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom

    X
  • Anil Wipat,

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom

    X
  • Darren James Wilkinson,

    Affiliations: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Mathematics and Statistics, Newcastle University, Newcastle upon Tyne, United Kingdom

    X
  • David Lydall mail

    d.a.lydall@ncl.ac.uk

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Published: April 07, 2011
  • DOI: 10.1371/journal.pgen.1001362

About the Authors

Stephen Gregory Addinall, Eva-Maria Holstein, Min Yu, Kaye Chapman, A. Peter Banks, Hien-Ping Ngo, Adam Ciesiolka, Anil Wipat, David Lydall
Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless, Min Yu, Kaye Chapman, A. Peter Banks, Morgan Taschuk, Alexander Young, Adam Ciesiolka, Allyson Lurena Lister, Anil Wipat, Darren James Wilkinson, David Lydall
Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
Laura Maringele
Crucible Laboratory, Institute for Ageing and Health, Newcastle University Centre for Life, Newcastle upon Tyne, United Kingdom
Morgan Taschuk, Allyson Lurena Lister, Anil Wipat
School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom
Alexander Young, Darren James Wilkinson
School of Mathematics and Statistics, Newcastle University, Newcastle upon Tyne, United Kingdom

Corresponding Author

Email: d.a.lydall@ncl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SGA EMH CL MY KC APB HPN LM DJW DL. Performed the experiments: SGA EMH CL MY KC APB HPN LM AC. Analyzed the data: SGA EMH CL MY KC APB HPN AY DJW DL. Contributed reagents/materials/analysis tools: LM MT ALL AW DJW. Wrote the paper: SGA EMH CL DJW DL.