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Research Article

Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti–dsDNA Autoantibody Production

  • Sharon A. Chung mail,

    sharon.chung@ucsf.edu (SAC); lindsey.criswell@ucsf.edu (LAC)

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Kimberly E. Taylor,

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Robert R. Graham,

    Affiliation: ITGR Human Genetics, Genentech, South San Francisco, California, United States of America

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  • Joanne Nititham,

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Annette T. Lee,

    Affiliation: Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, United States of America

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  • Ward A. Ortmann,

    Affiliation: ITGR Human Genetics, Genentech, South San Francisco, California, United States of America

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  • Chaim O. Jacob,

    Affiliation: Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Marta E. Alarcón-Riquelme,

    Affiliations: Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden, Andalusian Center for Genomics and Oncological Research, Pfizer-University of Granada-Junta de Andalucía, Granada, Spain, Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Betty P. Tsao,

    Affiliation: Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • John B. Harley,

    Affiliation: US Department of Veterans Affairs Medical Center and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • Patrick M. Gaffney,

    Affiliation: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Kathy L. Moser,

    Affiliation: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • SLEGEN,

    For membership of The International Consortium on the Genetics of Systemic Lupus Erythematosus please see the Acknowledgments.

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  • Michelle Petri,

    Affiliation: Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • F. Yesim Demirci,

    Affiliation: Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • M. Ilyas Kamboh,

    Affiliation: Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Susan Manzi,

    Affiliation: Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

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  • Peter K. Gregersen,

    Affiliation: Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, United States of America

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  • Carl D. Langefeld,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Wake Forest, North Carolina, United States of America

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  • Timothy W. Behrens,

    Affiliation: ITGR Human Genetics, Genentech, South San Francisco, California, United States of America

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  • Lindsey A. Criswell mail

    sharon.chung@ucsf.edu (SAC); lindsey.criswell@ucsf.edu (LAC)

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Published: March 03, 2011
  • DOI: 10.1371/journal.pgen.1001323

About the Authors

Sharon A. Chung, Kimberly E. Taylor, Joanne Nititham, Lindsey A. Criswell
Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Robert R. Graham, Ward A. Ortmann, Timothy W. Behrens
ITGR Human Genetics, Genentech, South San Francisco, California, United States of America
Annette T. Lee, Peter K. Gregersen
Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, United States of America
Chaim O. Jacob
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Marta E. Alarcón-Riquelme
Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
Marta E. Alarcón-Riquelme
Andalusian Center for Genomics and Oncological Research, Pfizer-University of Granada-Junta de Andalucía, Granada, Spain
Marta E. Alarcón-Riquelme, Patrick M. Gaffney, Kathy L. Moser
Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
Betty P. Tsao
Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
John B. Harley
US Department of Veterans Affairs Medical Center and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
Michelle Petri
Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
F. Yesim Demirci, M. Ilyas Kamboh
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Susan Manzi
Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America
Carl D. Langefeld
Department of Biostatistical Sciences, Wake Forest University Health Sciences, Wake Forest, North Carolina, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAC LAC. Performed the experiments: SAC KET JN. Analyzed the data: SAC KET. Contributed reagents/materials/analysis tools: SAC KET RRG JN ATL WAO COJ MEAR BPT JBH PMG KLM MP FYD MIK SM PKG CDL TWB LAC. Wrote the paper: SAC LAC.