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Research Article

SUMO-Targeted Ubiquitin Ligase, Rad60, and Nse2 SUMO Ligase Suppress Spontaneous Top1–Mediated DNA Damage and Genome Instability

  • Johanna Heideker,

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • John Prudden,

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • J. Jefferson P. Perry,

    Affiliations: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America, School of Biotechnology, Amrita Vishwa Vidya Peetham, Amritapuri, Kerala, India

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  • John A. Tainer,

    Affiliations: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America, Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Michael N. Boddy mail

    nboddy@scripps.edu

    Affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Published: March 03, 2011
  • DOI: 10.1371/journal.pgen.1001320

About the Authors

Johanna Heideker, John Prudden, J. Jefferson P. Perry, John A. Tainer, Michael N. Boddy
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
J. Jefferson P. Perry
School of Biotechnology, Amrita Vishwa Vidya Peetham, Amritapuri, Kerala, India
John A. Tainer
Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Corresponding Author

Email: nboddy@scripps.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JH JP JJPP JAT MNB. Performed the experiments: JH JP MNB. Analyzed the data: JH JP MNB. Wrote the paper: JH JP JJPP JAT MNB.