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Research Article

Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes

  • Kimberly E. Taylor,

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Sharon A. Chung,

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Robert R. Graham,

    Affiliation: ITGR Human Genetics, Genentech, South San Francisco, California, United States of America

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  • Ward A. Ortmann,

    Affiliation: ITGR Human Genetics, Genentech, South San Francisco, California, United States of America

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  • Annette T. Lee,

    Affiliation: Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, United States of America

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  • Carl D. Langefeld,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Wake Forest, North Carolina, United States of America

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  • Chaim O. Jacob,

    Affiliation: Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • M. Ilyas Kamboh,

    Affiliation: Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America

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  • Marta E. Alarcón-Riquelme,

    Affiliations: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Center for Genomics and Oncological Research, Pfizer-University of Granada-Junta de Andalucia, Granada, Spain

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  • Betty P. Tsao,

    Affiliation: Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Kathy L. Moser,

    Affiliation: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Patrick M. Gaffney,

    Affiliation: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • John B. Harley,

    Affiliations: U.S. Department of Veterans Affairs Medical Center Cincinnati, Ohio, United States of America, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • Michelle Petri,

    Affiliation: Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Susan Manzi,

    Affiliation: Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

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  • Peter K. Gregersen,

    Affiliation: Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, United States of America

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  • Timothy W. Behrens,

    Affiliation: ITGR Human Genetics, Genentech, South San Francisco, California, United States of America

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  • Lindsey A. Criswell mail

    lindsey.criswell@ucsf.edu

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Published: February 17, 2011
  • DOI: 10.1371/journal.pgen.1001311

About the Authors

Kimberly E. Taylor, Sharon A. Chung, Lindsey A. Criswell
Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Robert R. Graham, Ward A. Ortmann, Timothy W. Behrens
ITGR Human Genetics, Genentech, South San Francisco, California, United States of America
Annette T. Lee, Peter K. Gregersen
Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, United States of America
Carl D. Langefeld
Department of Biostatistical Sciences, Wake Forest University Health Sciences, Wake Forest, North Carolina, United States of America
Chaim O. Jacob
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
M. Ilyas Kamboh
Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America
Marta E. Alarcón-Riquelme, Kathy L. Moser, Patrick M. Gaffney
Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
Marta E. Alarcón-Riquelme
Center for Genomics and Oncological Research, Pfizer-University of Granada-Junta de Andalucia, Granada, Spain
Betty P. Tsao
Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
John B. Harley
U.S. Department of Veterans Affairs Medical Center Cincinnati, Ohio, United States of America
John B. Harley
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
Michelle Petri
Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Susan Manzi
Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America

Corresponding Author

Email: lindsey.criswell@ucsf.edu

Competing Interests

RRG and TWB are full-time employees of Genentech.

Author Contributions

Conceived and designed the experiments: KET SAC RRG PKG TWB LAC. Analyzed the data: KET CDL. Contributed reagents/materials/analysis tools: RRG WAO COJ PKG TWB. Wrote the paper: KET. Performed genotyping: ATL. Recruited subjects and collected data: MIK MEAR BPT KLM PMG JBH SM MP.