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Research Article

Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma

  • Kerry N. Veth,

    Affiliation: Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • Jason R. Willer,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky, United States of America

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  • Ross F. Collery,

    Affiliation: Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • Matthew P. Gray,

    Affiliation: Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • Gregory B. Willer,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky, United States of America

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  • Daniel S. Wagner,

    Affiliation: Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America

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  • Mary C. Mullins,

    Affiliation: Department of Cell and Developmental Biology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America

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  • Ava J. Udvadia,

    Affiliation: Department of Biological Sciences, University of Wisconsin–Milwaukee, Milwaukee, Wisconsin, United States of America

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  • Richard S. Smith,

    Affiliation: Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, Maine, United States of America

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  • Simon W. M. John,

    Affiliation: Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, Maine, United States of America

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  • Ronald G. Gregg,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky, United States of America

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  • Brian A. Link mail

    blink@mcw.edu

    Affiliation: Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • Published: February 17, 2011
  • DOI: 10.1371/journal.pgen.1001310

About the Authors

Kerry N. Veth, Ross F. Collery, Matthew P. Gray, Brian A. Link
Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
Jason R. Willer, Gregory B. Willer, Ronald G. Gregg
Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky, United States of America
Daniel S. Wagner
Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America
Mary C. Mullins
Department of Cell and Developmental Biology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America
Ava J. Udvadia
Department of Biological Sciences, University of Wisconsin–Milwaukee, Milwaukee, Wisconsin, United States of America
Richard S. Smith, Simon W. M. John
Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, Maine, United States of America

Corresponding Author

Email: blink@mcw.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KNV RFC SWMJ RGG BAL. Performed the experiments: KNV JRW RFC MPG GBW RSS SWMJ BAL. Analyzed the data: KNV JRW RFC GBW RSS SWMJ RGG BAL. Contributed reagents/materials/analysis tools: KNV JRW RFC DSW MCM AJU RGG BAL. Wrote the paper: KNV BAL.