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Research Article

Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE

  • Ellen M. Wijsman mail,

    wijsman@u.washington.edu

    Affiliations: Division of Medical Genetics, University of Washington, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

    X
  • Nathan D. Pankratz,

    Affiliation: Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • Yoonha Choi,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

    X
  • Joseph H. Rothstein,

    Affiliation: Division of Medical Genetics, University of Washington, Seattle, Washington, United States of America

    X
  • Kelley M. Faber,

    Affiliation: Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

    X
  • Rong Cheng,

    Affiliation: The Gertrude H. Sergievsky Center, The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

    X
  • Joseph H. Lee,

    Affiliation: The Gertrude H. Sergievsky Center, The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

    X
  • Thomas D. Bird,

    Affiliations: Division of Medical Genetics, University of Washington, Seattle, Washington, United States of America, Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Division, Seattle, Washington, United States of America, Department of Neurology, University of Washington, Seattle, Washington, United States of America

    X
  • David A. Bennett,

    Affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America

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  • Ramon Diaz-Arrastia,

    Affiliation: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Alison M. Goate,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Martin Farlow,

    Affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • Bernardino Ghetti,

    Affiliation: Department of Pathology, Division of Neuropathology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • Robert A. Sweet,

    Affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Tatiana M. Foroud,

    Affiliation: Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • Richard Mayeux,

    Affiliation: The Gertrude H. Sergievsky Center, The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

    X
  • The NIA-LOAD/NCRAD Family Study Group
  • Published: February 17, 2011
  • DOI: 10.1371/journal.pgen.1001308

About the Authors

Ellen M. Wijsman, Joseph H. Rothstein, Thomas D. Bird
Division of Medical Genetics, University of Washington, Seattle, Washington, United States of America
Ellen M. Wijsman, Yoonha Choi
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
Nathan D. Pankratz, Kelley M. Faber, Tatiana M. Foroud
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Rong Cheng, Joseph H. Lee, Richard Mayeux
The Gertrude H. Sergievsky Center, The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
Thomas D. Bird
Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Division, Seattle, Washington, United States of America
Thomas D. Bird
Department of Neurology, University of Washington, Seattle, Washington, United States of America
David A. Bennett
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America
Ramon Diaz-Arrastia
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Alison M. Goate
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America
Martin Farlow
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Bernardino Ghetti
Department of Pathology, Division of Neuropathology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Robert A. Sweet
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Corresponding Author

Email: wijsman@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EMW NDP JHL TMF RM. Analyzed the data: EMW NDP YC JHR KMF RC JHL. Contributed reagents/materials/analysis tools: TDB DAB RDA AMG MF BG RAS TMF RM. Wrote the paper: EMW NDP YC JHR JHL TDB DAB RDA AMG MF RAS TMF RM. Managed the data: KMF.