Advertisement
Research Article

A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

  • Eleonora A. M. Festen equal contributor,

    equal contributor Contributed equally to this work with: Eleonora A. M. Festen, Philippe Goyette, Todd Green

    Affiliations: Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands, Department of Genetics, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

    X
  • Philippe Goyette equal contributor,

    equal contributor Contributed equally to this work with: Eleonora A. M. Festen, Philippe Goyette, Todd Green

    Affiliation: Research Center, Université de Montréal and the Montreal Heart Institute, Montreal, Quebec, Canada

    X
  • Todd Green equal contributor,

    equal contributor Contributed equally to this work with: Eleonora A. M. Festen, Philippe Goyette, Todd Green

    Affiliation: The Broad Institute, Cambridge, Massachusetts, United States of America

    X
  • Gabrielle Boucher,

    Affiliation: Research Center, Université de Montréal and the Montreal Heart Institute, Montreal, Quebec, Canada

    X
  • Claudine Beauchamp,

    Affiliation: Research Center, Université de Montréal and the Montreal Heart Institute, Montreal, Quebec, Canada

    X
  • Gosia Trynka,

    Affiliation: Department of Genetics, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

    X
  • Patrick C. Dubois,

    Affiliation: Centre for Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Caroline Lagacé,

    Affiliation: Research Center, Université de Montréal and the Montreal Heart Institute, Montreal, Quebec, Canada

    X
  • Pieter C. F. Stokkers,

    Affiliation: Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands

    X
  • Daan W. Hommes,

    Affiliation: Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands

    X
  • Donatella Barisani,

    Affiliation: Department of Experimental Medicine, Faculty of Medicine, University of Milano-Bicocca, Monza, Italy

    X
  • Orazio Palmieri,

    Affiliation: U. O. Gastroenterologia ed Endoscopia Digestiva, Ospedale “Casa Sollievo della Sofferenza”, IRCCS, San Giovanni Rotondo, Italy

    X
  • Vito Annese,

    Affiliation: U. O. Gastroenterologia ed Endoscopia Digestiva, Ospedale “Casa Sollievo della Sofferenza”, IRCCS, San Giovanni Rotondo, Italy

    X
  • David A. van Heel,

    Affiliation: Centre for Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Rinse K. Weersma mail,

    R.K.Weersma@int.umcg.nl (RKW); john.david.rioux@umontreal.ca (JDR)

    Affiliation: Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

    These authors also contributed equally to this work.

    X
  • Mark J. Daly ,

    Affiliations: The Broad Institute, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    These authors also contributed equally to this work.

    X
  • Cisca Wijmenga ,

    Affiliation: Department of Genetics, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

    These authors also contributed equally to this work.

    X
  • John D. Rioux mail

    R.K.Weersma@int.umcg.nl (RKW); john.david.rioux@umontreal.ca (JDR)

    Affiliation: Research Center, Université de Montréal and the Montreal Heart Institute, Montreal, Quebec, Canada

    These authors also contributed equally to this work.

    X
  • Published: January 27, 2011
  • DOI: 10.1371/journal.pgen.1001283

About the Authors

Eleonora A. M. Festen, Rinse K. Weersma
Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Eleonora A. M. Festen, Gosia Trynka, Cisca Wijmenga
Department of Genetics, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
Philippe Goyette, Gabrielle Boucher, Claudine Beauchamp, Caroline Lagacé, John D. Rioux
Research Center, Université de Montréal and the Montreal Heart Institute, Montreal, Quebec, Canada
Todd Green, Mark J. Daly
The Broad Institute, Cambridge, Massachusetts, United States of America
Patrick C. Dubois, David A. van Heel
Centre for Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Pieter C. F. Stokkers
Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
Daan W. Hommes
Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands
Donatella Barisani
Department of Experimental Medicine, Faculty of Medicine, University of Milano-Bicocca, Monza, Italy
Orazio Palmieri, Vito Annese
U. O. Gastroenterologia ed Endoscopia Digestiva, Ospedale “Casa Sollievo della Sofferenza”, IRCCS, San Giovanni Rotondo, Italy
Mark J. Daly
Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EAMF PG TG MJD CW JDR. Performed the experiments: CB PCD CL DAvH. Analyzed the data: EAMF PG TG GB CB GT PCD CL DAvH MJD CW JDR. Contributed reagents/materials/analysis tools: PCFS DWH DB OP VA DAvH RKW CW JDR. Wrote the paper: EAMF PG TG GB CB RKW MJD CW JDR.