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Research Article

Friedreich's Ataxia (GAA)n•(TTC)n Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae

  • Wei Tang,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Margaret Dominska,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Patricia W. Greenwell,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Zachary Harvanek,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Kirill S. Lobachev,

    Affiliation: School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Hyun-Min Kim,

    Affiliation: School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

    Current address: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Vidhya Narayanan,

    Affiliation: School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Sergei M. Mirkin,

    Affiliation: Department of Biology, Tufts University, Medford, Massachusetts, United States of America

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  • Thomas D. Petes mail

    tom.petes@duke.edu

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Published: January 13, 2011
  • DOI: 10.1371/journal.pgen.1001270

About the Authors

Wei Tang, Margaret Dominska, Patricia W. Greenwell, Zachary Harvanek, Thomas D. Petes
Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America
Kirill S. Lobachev, Hyun-Min Kim, Vidhya Narayanan
School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America
Sergei M. Mirkin
Department of Biology, Tufts University, Medford, Massachusetts, United States of America

Corresponding Author

Email: tom.petes@duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WT ZH KSL HMK VN SMM TDP. Performed the experiments: WT MD PWG ZH HMK VN SMM. Analyzed the data: WT MD PWG ZH KSL SMM TDP. Contributed reagents/materials/analysis tools: WT KSL HMK. Wrote the paper: WT KSL SMM TDP.