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Research Article

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

  • Clement T. Y. Chan,

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Madhu Dyavaiah,

    Affiliation: Department of Biomedical Sciences, Gen*NY*sis Center for Excellence in Cancer Genomics, University at Albany, State University of New York, Rensselaer, New York, United States of America

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  • Michael S. DeMott,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Koli Taghizadeh,

    Affiliation: Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Peter C. Dedon mail,

    pcdedon@mit.edu (PCD); tbegley@albany.edu (TJB)

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Thomas J. Begley mail

    pcdedon@mit.edu (PCD); tbegley@albany.edu (TJB)

    Affiliation: Department of Biomedical Sciences, Gen*NY*sis Center for Excellence in Cancer Genomics, University at Albany, State University of New York, Rensselaer, New York, United States of America

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  • Published: December 16, 2010
  • DOI: 10.1371/journal.pgen.1001247

About the Authors

Clement T. Y. Chan, Michael S. DeMott, Peter C. Dedon
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Clement T. Y. Chan
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Madhu Dyavaiah, Thomas J. Begley
Department of Biomedical Sciences, Gen*NY*sis Center for Excellence in Cancer Genomics, University at Albany, State University of New York, Rensselaer, New York, United States of America
Koli Taghizadeh, Peter C. Dedon
Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CTYC PCD TJB. Performed the experiments: CTYC MSD. Analyzed the data: CTYC MD MSD KT PCD TJB. Contributed reagents/materials/analysis tools: CTYC MD TJB. Wrote the paper: CTYC MD MSD KT PCD TJB.