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Research Article

Histone Deacetylases Suppress CGG Repeat–Induced Neurodegeneration Via Transcriptional Silencing in Models of Fragile X Tremor Ataxia Syndrome

  • Peter K. Todd mail,

    petertod@umich.edu

    Affiliation: Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Seok Yoon Oh,

    Affiliation: Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Amy Krans,

    Affiliation: Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Udai B. Pandey,

    Affiliation: Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America

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  • Nicholas A. Di Prospero,

    Affiliation: Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America

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  • Kyung-Tai Min,

    Affiliation: Department of Biology, University of Indiana, Bloomington, Indiana, United States of America

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  • J. Paul Taylor,

    Affiliation: Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Henry L. Paulson

    Affiliation: Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: December 09, 2010
  • DOI: 10.1371/journal.pgen.1001240

About the Authors

Peter K. Todd, Seok Yoon Oh, Amy Krans, Henry L. Paulson
Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America
Udai B. Pandey
Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
Nicholas A. Di Prospero
Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America
Kyung-Tai Min
Department of Biology, University of Indiana, Bloomington, Indiana, United States of America
J. Paul Taylor
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

Corresponding Author

Email: petertod@umich.edu

Competing Interests

Dr Nicholas A. Di Prospero is a current employee of Johnson and Johnson Pharmaceutical Research and Development.

Author Contributions

Conceived and designed the experiments: PKT UBP JPT HLP. Performed the experiments: PKT SYO AK. Analyzed the data: PKT SYO AK JPT HLP. Contributed reagents/materials/analysis tools: PKT UBP NADP KTM JPT HLP. Wrote the paper: PKT JPT HLP.