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Research Article

Identification of Y-Box Binding Protein 1 As a Core Regulator of MEK/ERK Pathway-Dependent Gene Signatures in Colorectal Cancer Cells

  • Karsten Jürchott,

    Affiliation: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany

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  • Ralf-Jürgen Kuban,

    Affiliation: Laboratory of Functional Genomics, Universitätsmedizin Berlin, Berlin, Germany

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  • Till Krech,

    Affiliation: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany

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  • Nils Blüthgen,

    Affiliation: Institute for Theoretical Biology, Humboldt University, Berlin, Germany

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  • Ulrike Stein,

    Affiliation: Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Wolfgang Walther,

    Affiliation: Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Christian Friese,

    Affiliation: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany

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  • Szymon M. Kiełbasa,

    Affiliations: Institute for Theoretical Biology, Humboldt University, Berlin, Germany, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Ute Ungethüm,

    Affiliation: Laboratory of Functional Genomics, Universitätsmedizin Berlin, Berlin, Germany

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  • Per Lund,

    Affiliation: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany

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  • Thomas Knösel,

    Affiliation: Institute of Pathology, Friedrich-Schiller-University Jena, Jena, Germany

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  • Wolfgang Kemmner,

    Affiliations: Max Delbrück Center for Molecular Medicine, Berlin, Germany, Charité Comprehensive Cancer Center, Berlin, Germany

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  • Markus Morkel,

    Affiliations: Max Delbrück Center for Molecular Medicine, Berlin, Germany, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Johannes Fritzmann,

    Affiliation: Charité Comprehensive Cancer Center, Berlin, Germany

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  • Peter M. Schlag,

    Affiliation: Charité Comprehensive Cancer Center, Berlin, Germany

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  • Walter Birchmeier,

    Affiliation: Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Tammo Krueger,

    Affiliation: Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Silke Sperling,

    Affiliation: Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Christine Sers,

    Affiliation: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany

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  • Hans-Dieter Royer,

    Affiliations: Center of Advanced European Studies and Research, Bonn, Germany, Institute of Human Genetics and Anthropology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany

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  • Hanspeter Herzel,

    Affiliation: Institute for Theoretical Biology, Humboldt University, Berlin, Germany

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  • Reinhold Schäfer mail

    reinhold.schaefer@charite.de

    Affiliations: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany, Laboratory of Functional Genomics, Universitätsmedizin Berlin, Berlin, Germany, Charité Comprehensive Cancer Center, Berlin, Germany

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  • Published: December 02, 2010
  • DOI: 10.1371/journal.pgen.1001231

About the Authors

Karsten Jürchott, Till Krech, Christian Friese, Per Lund, Christine Sers, Reinhold Schäfer
Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany
Ralf-Jürgen Kuban, Ute Ungethüm, Reinhold Schäfer
Laboratory of Functional Genomics, Universitätsmedizin Berlin, Berlin, Germany
Nils Blüthgen, Szymon M. Kiełbasa, Hanspeter Herzel
Institute for Theoretical Biology, Humboldt University, Berlin, Germany
Ulrike Stein, Wolfgang Walther, Wolfgang Kemmner, Markus Morkel, Walter Birchmeier
Max Delbrück Center for Molecular Medicine, Berlin, Germany
Szymon M. Kiełbasa, Markus Morkel, Tammo Krueger, Silke Sperling
Max Planck Institute for Molecular Genetics, Berlin, Germany
Thomas Knösel
Institute of Pathology, Friedrich-Schiller-University Jena, Jena, Germany
Wolfgang Kemmner, Johannes Fritzmann, Peter M. Schlag, Reinhold Schäfer
Charité Comprehensive Cancer Center, Berlin, Germany
Hans-Dieter Royer
Center of Advanced European Studies and Research, Bonn, Germany
Hans-Dieter Royer
Institute of Human Genetics and Anthropology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany

Corresponding Author

Email: reinhold.schaefer@charite.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K Jürchott, H Herzel, R Schäfer. Performed the experiments: K Jürchott, T Krech, U Stein, W Walther, C Friese, U Ungethüm, P Lund, T Knösel, W Kemmner, M Morkel. Analyzed the data: K Jürchott, RJ Kuban, N Blüthgen, U Stein, W Walther, SM Kielbasa, T Knösel, W Kemmner, J Fritzmann, T Krueger, S Sperling, C Sers, H Herzel, R Schäfer. Contributed reagents/materials/analysis tools: K Jürchott, N Blüthgen, M Morkel, J Fritzmann, PM Schlag, W Birchmeier, C Sers, HD Royer. Wrote the paper: K Jürchott, N Blüthgen, R Schäfer.