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Research Article

CTCF-Dependent Chromatin Bias Constitutes Transient Epigenetic Memory of the Mother at the H19-Igf2 Imprinting Control Region in Prospermatogonia

  • Dong-Hoon Lee equal contributor,

    equal contributor Contributed equally to this work with: Dong-Hoon Lee, Purnima Singh

    Affiliation: Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    X
  • Purnima Singh equal contributor,

    equal contributor Contributed equally to this work with: Dong-Hoon Lee, Purnima Singh

    Affiliation: Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    X
  • Shirley Y. Tsai,

    Affiliation: Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    X
  • Nathan Oates,

    Affiliation: Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    X
  • Alexander Spalla,

    Affiliation: Shared Recourses, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    X
  • Claudio Spalla,

    Affiliation: Shared Recourses, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    X
  • Lucy Brown,

    Affiliation: Shared Recourses, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    X
  • Guillermo Rivas,

    Affiliation: Department of Molecular Medicine, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    X
  • Garrett Larson,

    Affiliation: Department of Molecular Medicine, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    X
  • Tibor A. Rauch,

    Affiliation: Department of Biology, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    Current address: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America

    X
  • Gerd P. Pfeifer,

    Affiliation: Department of Molecular Medicine, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    X
  • Piroska E. Szabó mail

    pszabo@coh.org

    Affiliation: Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

    X
  • Published: November 24, 2010
  • DOI: 10.1371/journal.pgen.1001224

About the Authors

Dong-Hoon Lee, Purnima Singh, Shirley Y. Tsai, Nathan Oates, Piroska E. Szabó
Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America
Alexander Spalla, Claudio Spalla, Lucy Brown
Shared Recourses, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America
Guillermo Rivas, Garrett Larson, Gerd P. Pfeifer
Department of Molecular Medicine, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America
Tibor A. Rauch
Department of Biology, Beckman Research Institute, City of Hope National Medical Centre, Duarte, California, United States of America

Corresponding Author

Email: pszabo@coh.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PS PES. Performed the experiments: DHL PS SYT NO AS CS GR GL TAR PES. Analyzed the data: DHL PS SYT NO GR GL TAR GPP PES. Contributed reagents/materials/analysis tools: LB GR GL TAR GPP. Wrote the paper: PES.