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Research Article

Systematic Dissection and Trajectory-Scanning Mutagenesis of the Molecular Interface That Ensures Specificity of Two-Component Signaling Pathways

  • Emily J. Capra equal contributor,

    equal contributor Contributed equally to this work with: Emily J. Capra, Barrett S. Perchuk

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Barrett S. Perchuk equal contributor,

    equal contributor Contributed equally to this work with: Emily J. Capra, Barrett S. Perchuk

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Emma A. Lubin,

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Orr Ashenberg,

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Jeffrey M. Skerker,

    Affiliations: Department of Bioengineering, University of California Berkeley, Berkeley, California, United States of America, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Michael T. Laub mail

    laub@mit.edu

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: November 24, 2010
  • DOI: 10.1371/journal.pgen.1001220

About the Authors

Emily J. Capra, Barrett S. Perchuk, Emma A. Lubin, Orr Ashenberg, Michael T. Laub
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Barrett S. Perchuk, Michael T. Laub
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Jeffrey M. Skerker
Department of Bioengineering, University of California Berkeley, Berkeley, California, United States of America
Jeffrey M. Skerker
Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Corresponding Author

Email: laub@mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EJC BSP EAL JMS MTL. Performed the experiments: EJC BSP EAL OA. Analyzed the data: EJC BSP EAL OA MTL. Contributed reagents/materials/analysis tools: EJC BSP OA JMS. Wrote the paper: EJC MTL.