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Research Article

Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A

  • Carola Marzi equal contributor,

    equal contributor Contributed equally to this work with: Carola Marzi, Eva Albrecht

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Eva Albrecht equal contributor,

    equal contributor Contributed equally to this work with: Carola Marzi, Eva Albrecht

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Pirro G. Hysi,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Vasiliki Lagou,

    Affiliations: Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Melanie Waldenberger,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Anke Tönjes,

    Affiliations: Department of Medicine, University of Leipzig, Leipzig, Germany, Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany

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  • Inga Prokopenko,

    Affiliations: Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Katharina Heim,

    Affiliation: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Hannah Blackburn,

    Affiliation: Wellcome Trust Sanger Institute Genome Campus, Hinxton, United Kingdom

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  • Janina S. Ried,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Marcus E. Kleber,

    Affiliation: LURIC, Freiburg, Germany

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  • Massimo Mangino,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Barbara Thorand,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Annette Peters,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Christopher J. Hammond,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Harald Grallert,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Bernhard O. Boehm,

    Affiliation: Division of Endocrinology, Department of Medicine, University of Ulm, Ulm, Germany

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  • Peter Kovacs,

    Affiliation: Interdisciplinary Centre for Clinical Research, Department of Internal Medicine III, University of Leipzig, Leipzig, Germany

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  • Ludwig Geistlinger,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Holger Prokisch,

    Affiliations: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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  • Bernhard R. Winkelmann,

    Affiliation: Cardiology Group Sachsenhausen, Frankfurt, Germany

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  • Tim D. Spector,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • H.-Erich Wichmann,

    Affiliations: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany, Klinikum Grosshadern, Munich, Germany

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  • Michael Stumvoll,

    Affiliation: Department of Medicine, University of Leipzig, Leipzig, Germany

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  • Nicole Soranzo,

    Affiliations: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Sanger Institute Genome Campus, Hinxton, United Kingdom

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  • Winfried März,

    Affiliations: SynLab Medizinisches Versorgungszentrum Heidelberg, Eppelheim, Germany, Institut für Public Health, Sozialmedizin und Epidemiologie, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Graz, Austria

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  • Wolfgang Koenig,

    Affiliation: Department of Internal Medicine II – Cardiology, University of Ulm Medical Center, Ulm, Germany

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  • Thomas Illig mail,

    illig@helmholtz-muenchen.de (TI); christian.gieger@helmholtz-muenchen.de (CG)

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    These authors also contributed equally to this work.

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  • Christian Gieger mail

    illig@helmholtz-muenchen.de (TI); christian.gieger@helmholtz-muenchen.de (CG)

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    These authors also contributed equally to this work.

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  • Published: November 18, 2010
  • DOI: 10.1371/journal.pgen.1001213

About the Authors

Carola Marzi, Eva Albrecht, Melanie Waldenberger, Janina S. Ried, Barbara Thorand, Annette Peters, Harald Grallert, Ludwig Geistlinger, H.-Erich Wichmann, Thomas Illig, Christian Gieger
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Pirro G. Hysi, Massimo Mangino, Christopher J. Hammond, Tim D. Spector, Nicole Soranzo
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
Vasiliki Lagou, Inga Prokopenko
Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom
Vasiliki Lagou, Inga Prokopenko
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Anke Tönjes, Michael Stumvoll
Department of Medicine, University of Leipzig, Leipzig, Germany
Anke Tönjes
Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany
Katharina Heim, Holger Prokisch
Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Hannah Blackburn, Nicole Soranzo
Wellcome Trust Sanger Institute Genome Campus, Hinxton, United Kingdom
Marcus E. Kleber
LURIC, Freiburg, Germany
Bernhard O. Boehm
Division of Endocrinology, Department of Medicine, University of Ulm, Ulm, Germany
Peter Kovacs
Interdisciplinary Centre for Clinical Research, Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
Holger Prokisch
Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
Bernhard R. Winkelmann
Cardiology Group Sachsenhausen, Frankfurt, Germany
H.-Erich Wichmann
Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
H.-Erich Wichmann
Klinikum Grosshadern, Munich, Germany
Winfried März
SynLab Medizinisches Versorgungszentrum Heidelberg, Eppelheim, Germany
Winfried März
Institut für Public Health, Sozialmedizin und Epidemiologie, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany
Winfried März
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Graz, Austria
Wolfgang Koenig
Department of Internal Medicine II – Cardiology, University of Ulm Medical Center, Ulm, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Performed the experiments: HG. Analyzed the data: CM EA PGH VL IP KH JSR. Wrote the paper: CM. Oversight: CG BOB BRW TDS HEW MS NS WM TI. Conducted meta-analysis: EA. Phenotyping, genotyping, gene expression profiling: MW AT HB MEK MM BT AP CJH PK LG HP WK.